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A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers

Author
FRAY, M. Jonathan1 ; DICKINSON, Roger P1 ; HUGGINS, John P2 ; OCCLESTON, Nicholas L2
[1] Department of Discovery Chemistry, Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, United Kingdom
[2] Department of Discovery Biology, Pfizer Global Research and Development, Sandwich, Kent, CT13 9NJ, United Kingdom
Source

Journal of medicinal chemistry (Print). 2003, Vol 46, Num 16, pp 3514-3525, 12 p ; ref : 60 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Acide carboxylique Activité biologique Animal Benzène dérivé Biphényle dérivé Carboxamide Chimiothérapie Chronique Composé aliphatique Ex vivo Homme In vitro Inhibiteur enzyme Kératinocyte Lapin Migration Peau pathologie Peau Plaie Stromelysin 1 Synthèse chimique Sélectivité Traitement Ulcère Voie externe Voie percutanée Caproïque acide3-[(2,2-diméthyl-1-[(2-méthoxy-1-phényléthyl)carbamoyl]propyl)carbamoyl]-6-[2-méthylbiphényl-4-yl] UK 370106 Enzyme Hydrolases Lagomorpha Mammalia Metalloendopeptidases Peptidases Vertebrata
Keyword (en)
Carboxylic acid Biological activity Animal Benzene derivatives Biphenyl derivatives Carboxamide Chemotherapy Chronic Aliphatic compound Ex vivo Human In vitro Enzyme inhibitor Keratinocyte Rabbit Migration Skin disease Skin Wound Stromelysin 1 Chemical synthesis Selectivity Treatment Ulcer Topical administration Percutaneous route Enzyme Hydrolases Lagomorpha Mammalia Metalloendopeptidases Peptidases Vertebrata
Keyword (es)
Acido carboxílico Actividad biológica Animal Benceno derivado Bifenilo derivado Carboxamida Quimioterapia Crónico Compuesto alifático Ex vivo Hombre In vitro Inhibidor enzima Queratinocito Conejo Migración Piel patología Piel Herida Stromelysin 1 Síntesis química Selectividad Tratamiento Ulcera Vía externa Vía percutánea Enzima Hydrolases Lagomorpha Mammalia Metalloendopeptidases Peptidases Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02K Skin, nail, hair, dermoskeleton

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
15020452

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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