Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT2A/2C receptor ligands
- Author
- CHAMBERS, James J1 ; PARRISH, Jason C1 ; JENSEN, Niels H1 ; KURRASCH-ORBAUGH, Deborah M1 ; MARONA-LEWICKA, Danuta1 ; NICHOLS, David E1
[1] Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, United States - Source
Journal of medicinal chemistry (Print). 2003, Vol 46, Num 16, pp 3526-3535, 10 p ; ref : 28 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Agoniste partiel Amine primaire Animal Composé aromatique Composé tricyclique Hétérocycle oxygène In vitro Racémique Rat Relation structure activité Rigidité moléculaire Récepteur sérotoninergique 5-HT2A Récepteur sérotoninergique 5-HT2C Synthèse chimique Sélectivité Naphto[1,8-bc]furane(5-aminométhyl-8-bromo-4,5-dihydro-6-méthoxy) chlorhysrate Naphtofurane Brome Composé organique Mammalia Rodentia Vertebrata
- Keyword (en)
- Affinity Partial agonist Primary amine Animal Aromatic compound Tricyclic compound Oxygen heterocycle In vitro Racemic Rat Structure activity relation Molecular rigidity 5-HT2A serotonin receptor 5-HT2C serotonin receptor Chemical synthesis Selectivity Bromine Organic compounds Mammalia Rodentia Vertebrata
- Keyword (es)
- Afinidad Agonista parcial Amina primaria Animal Compuesto aromático Compuesto tricíclico Heterociclo oxígeno In vitro Racémico Rata Relación estructura actividad Rigidez molecular Receptor serotoninérgico 5-HT2A Receptor serotoninérgico 5-HT2C Síntesis química Selectividad Bromo Compuesto orgánico Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09C Serotoninergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15020453
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm030064v 
https://dx.doi.org/10.1021/jm030064v
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