Structure-based design of novel guanidine/benzamidine mimics: Potent and orally bioavailable factor Xa inhibitors as novel anticoagulants
- Author
- LAM, Patrick Y. S1 ; CLARK, Charles G1 ; ROSSI, Karen A1 ; WRIGHT, Matthew R1 ; BAI, Stephen A1 ; HE, Kan1 ; LUETTGEN, Joseph M1 ; WONG, Pancras C1 ; KNABB, Robert M1 ; WEXLER, Ruth R1 ; RENHUA LI1 ; PINTO, Donald J. P1 ; ORWAT, Michael J1 ; GALEMMO, Robert A1 ; FEVIG, John M1 ; TELEHA, Christopher A1 ; ALEXANDER, Richard S1 ; SMALLWOOD, Angela M1
[1] Bristol-Myers Squibb Company, P.O. Box 5400, Princeton, New Jersey 08542-5400, United States - Source
Journal of medicinal chemistry (Print). 2003, Vol 46, Num 21, pp 4405-4418, 14 p ; ref : 25 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Amidine Animal Anticoagulant Biodisponibilité Biphényle dérivé Chien Coagulation Factor Xa Inhibiteur enzyme Isoquinoléine dérivé Pharmacocinétique Pyrazole dérivé Relation structure activité Sulfonamide Synthèse chimique Voie intraveineuse Voie orale Pyrazole-5-carboxamide(1-[1-amino-7-isoquinolyl]-N-[2p-sulfonamido-p-biphénylyl]) Carnivora Enzyme Fissipedia Hydrolases Mammalia Peptidases Serine endopeptidases Vertebrata
- Keyword (en)
- Amidine Animal Anticoagulant Bioavailability Biphenyl derivatives Dog Coagulation Factor Xa Enzyme inhibitor Isoquinoline derivatives Pharmacokinetics Pyrazole derivatives Structure activity relation Sulfonamide Chemical synthesis Intravenous administration Oral administration Carnivora Enzyme Fissipedia Hydrolases Mammalia Peptidases Serine endopeptidases Vertebrata
- Keyword (es)
- Amidina Animal Anticoagulante Biodisponibilidad Bifenilo derivado Perro Coagulation Factor Xa Inhibidor enzima Isoquinoleína Farmacocinética Pirazol derivado Relación estructura actividad Sulfonamida Síntesis química Vía intravenosa Vía oral Carnivora Enzima Fissipedia Hydrolases Mammalia Peptidases Serine endopeptidases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02G Blood. Blood coagulation. Reticuloendothelial system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15202060
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm020578e 
https://dx.doi.org/10.1021/jm020578e
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