CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy
- Author
- PARDANANI, Animesh; KETTERLING, Rhett P; GILLILAND, D. Gary; DEWALD, Gordon W; TEFFERI, Ayalew; BROCKMAN, Stephanie R; FLYNN, Heather C; PATERNOSTER, Sarah F; SHEARER, Brandon M; REEDER, Terra L; LI, Chin-Yang; CROSS, Nicholas C. P; COOLS, Jan
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States
Divisions of Hematotogy and internal Medicine, Laboratory Genetics, and Hematopathology, Mayo Clinic, Rochester, MN, United Kingdom
Wessex Regional Genetics Laboratory, Salisbury District Hospital, Salisbury, United Kingdom - Source
Blood. 2003, Vol 102, Num 9, pp 3093-3096, 4 p ; ref : 25 ref
- ISSN
- 0006-4971
- Scientific domain
- Medical oncology; Hematology
- Publisher
- The Americain Society of Hematology, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Chimiothérapie Cytogénétique Délétion Eosinophilie Gène hybride Homme Hyperéosinophilie syndrome Inhibiteur enzyme Mastocytose Pathogénie Protein-tyrosine kinase Réarrangement génique Traitement Gène CHIC2 Gène FIP1L1 Gène PDGFRA Mésilate d'imatinib STI 571 Enzyme Génétique Hémopathie Transferases
- Keyword (en)
- Chemotherapy Cytogenetics Deletion Eosinophilia Hybrid gene Human Hypereosinophilic syndrome Enzyme inhibitor Mastocytosis Pathogenesis Protein-tyrosine kinase Gene rearrangement Treatment Imatinib mesylate Enzyme Genetics Hemopathy Transferases
- Keyword (es)
- Quimioterapia Citogenética Deleción Eosinofilia Gen híbrido Hombre Hipereosinofilia síndrome Inhibidor enzima Mastocitosis Patogenia Protein-tyrosine kinase Redisposición génica Tratamiento Enzima Genética Hemopatía Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02G Blood. Blood coagulation. Reticuloendothelial system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15235328
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1182/blood-2003-05-1627 
https://dx.doi.org/10.1182/blood-2003-05-1627
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