SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology
- Author
- DEKKER, P. B1 2 ; HOGENDOORN, P. C. W2 ; KUIPERS-DIJKSHOORN, N2 ; PRINS, F. A2 ; VAN DUINEN, S. G2 ; TASCHNER, P. E. M3 ; VAN DER MEY, A. G. L1 ; CORNELISSE, C. J2
[1] Department of Otorhinolaryngology, Leiden University Medical Centre, Leiden, Netherlands
[2] Department of Pathology, Leiden University Medical Centre, Leiden, Netherlands
[3] Department of Human and Clinical Genetics, Leiden University Medical Centre, Leiden, Netherlands - Source
Journal of pathology. 2003, Vol 201, Num 3, pp 480-486, 7 p ; ref : 30 ref
- CODEN
- JPTLAS
- ISSN
- 0022-3417
- Scientific domain
- Medical oncology; Medical laboratory techniques; General medicine general surgery
- Publisher
- Wiley, Chichester
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- SDHB SDHD complex II electron microscopy enzyme histochemistry head and neck paragangliomas immunohistochemistry mitochondria mutation analysis respiratory chain
- Keyword (fr)
- Analyse Chaîne respiratoire Diagnostic Expression génique Homme Immunohistochimie Microscopie électronique Mitochondrie Mutation Paragangliome Succinate dehydrogenase (ubiquinone) Tête cou Anatomopathologie Déterminisme génétique Enzyme Immunopathologie Oxidoreductases Système nerveux autonome pathologie Système nerveux pathologie Tumeur
- Keyword (en)
- Analysis Respiratory chain Diagnosis Gene expression Human Immunohistochemistry Electron microscopy Mitochondria Mutation Paraganglioma Succinate dehydrogenase (ubiquinone) Head and neck Anatomic pathology Genetic determinism Enzyme Immunopathology Oxidoreductases Diseases of the autonomic nervous system Nervous system diseases Tumor
- Keyword (es)
- Análisis Cadena respiratoria Diagnóstico Expresión genética Hombre Inmunohistoquímica Microscopía electrónica Mitocondria Mutación Paraganglioma Succinate dehydrogenase (ubiquinone) Cabeza cuello Anatomía patológica Determinismo genético Enzima Inmunopatología Oxidoreductases Sistema nervioso autónomo patología Sistema nervioso patología Tumor
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B10 Otorhinolaryngology. Stomatology / 002B10A Otorhinolaryngology (head neck, general aspects and miscellaneous) / 002B10A01 Tumors
- Discipline
- Otorhinolaryngology. Stomatology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15260084
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/path.1461 
https://dx.doi.org/10.1002/path.1461
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