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Discovery of a bulky 2-tert-butyl group containing primaquine analogue that exhibits potent blood-schizontocidal antimalarial activities and complete elimination of methemoglobin toxicity

Author
JAIN, Meenakshi1 ; VANGAPANDU, Suryanarayana1 ; SACHDEVA, Sandeep1 ; SINGH, Savita1 ; SINGH, Prati P1 ; JENA, Gopa B1 ; TIKOO, Kulbhushan1 ; RAMARAO, Poduri1 ; KAUL, Chaman L1 ; JAIN, Rahul1
[1] National Institute of Pharmaceutical Education and Research, Sector 67, S.A.S., Nagar, Punjab 160 062, India
Source

Journal of medicinal chemistry (Print). 2004, Vol 47, Num 2, pp 285-287, 3 p ; ref : 14 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Amine aromatique Amine primaire Animal Antipaludique Antiparasitaire Antiprotozoaire Chimiothérapie Composé aromatique Composé bicyclique Hétérocycle azote In vitro In vivo Méthémoglobine Paludisme Plasmodium berghei Plasmodium falciparum Plasmodium yoelii nigeriensis Sang Souris Synthèse chimique Toxicité Traitement Voie orale Quinoléine(8-[(4-amino-1-méthylbutyl)amino]-2-t-butyl-6-méthoxy) Apicomplexa Infection Mammalia Parasitose Protozoa Protozoose Rodentia Vertebrata
Keyword (en)
Aromatic amine Primary amine Animal Antimalarial Parasiticide Antiprotozoal agent Chemotherapy Aromatic compound Bicyclic compound Nitrogen heterocycle In vitro In vivo Methemoglobin Malaria Plasmodium berghei Plasmodium falciparum Plasmodium yoelii nigeriensis Blood Mouse Chemical synthesis Toxicity Treatment Oral administration Apicomplexa Infection Mammalia Parasitosis Protozoa Protozoal disease Rodentia Vertebrata
Keyword (es)
Amina aromática Amina primaria Animal Antipalúdico Antiparasitario Antiprotozoario Quimioterapia Compuesto aromático Compuesto bicíclico Heterociclo nitrógeno In vitro In vivo Metahemoglobina Paludismo Plasmodium berghei Plasmodium falciparum Plasmodium yoelii nigeriensis Sangre Ratón Síntesis química Toxicidad Tratamiento Vía oral Apicomplexa Infección Mammalia Parasitosis Protozoa Protozoosis Rodentia Vertebrata
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S06 Antiparasitic agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
15422695

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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