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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides

Author
CHAN, Laval1 ; PEREIRA, Oswy1 ; ROY, Caroline1 ; NASTURICA, Daniel1 ; MOINET, Christophe1 ; BETHELL, Richard1 ; HAMEL, Martine1 ; L'HEUREUX, Lucille1 ; DAVID, Maud1 ; NICOLAS, Olivier1 ; COURTEMANCHE-ASSELIN, Philippe1 ; BRUNETTE, Stéphanie1 ; JAGADEESWAR REDDY, T1 ; BILIMORIA, Darius2 ; BEDARD, Jean2 ; DAS, Sanjoy K1 ; POISSON, Carl1 ; COURCHESNE, Marc1 ; PROULX, Mélanie1 ; SIDDIQUI, Arshad1 ; YANNOPOULOS, Constantin G1 ; NGUYEN-BA, Nghe1
[1] Shire BioChem Inc., 275 Armand-Frappier, Laval, Quebec, H7V 4A7, Canada
[2] Shire BioChem Inc., 275 Armand-Frappier, Laval, Quebec, H7V 4A7, Canada
Source

Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 3, pp 797-800, 4 p ; ref : 10 ref

ISSN
0960-894X
Scientific domain
Biochemistry, molecular biology, biophysics; Pharmacology drugs
Publisher
Elsevier, Oxford
Publication country
United Kingdom
Document type
Article
Language
English
Keyword (fr)
Antiviral Benzène dérivé Carboxamide Composé monocyclique Conformation Cycle 5 chaînons Cycle développement virus Hétérocycle soufre In vitro Inhibiteur enzyme Inhibition Modèle moléculaire Modélisation RNA-directed RNA polymerase Relation structure activité Synthèse chimique Virus hépatite C Cyclohexanecarboxamide dérivé Protéine NS5B Thiophène-2-carboxylique acide(3-[isopropyl 4-méthylcyclohexanecarbonyl amino]-5-phényl) Enzyme Flaviviridae Hepacivirus Nucleotidyltransferases Transferases Virus
Keyword (en)
Antiviral Benzene derivatives Carboxamide Monocyclic compound Conformation Five membered ring Virus replication cycle Sulfur heterocycle In vitro Enzyme inhibitor Inhibition Molecular model Modeling RNA-directed RNA polymerase Structure activity relation Chemical synthesis Hepatitis C virus Enzyme Flaviviridae Hepacivirus Nucleotidyltransferases Transferases Virus
Keyword (es)
Antiviral Benceno derivado Carboxamida Compuesto monocíclico Conformación Ciclo 5 eslabones Ciclo desarrollo virus Heterociclo azufre In vitro Inhibidor enzima Inhibición Modelo molecular Modelización RNA-directed RNA polymerase Relación estructura actividad Síntesis química Hepatitis C virus Enzima Flaviviridae Hepacivirus Nucleotidyltransferases Transferases Virus
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
15478065

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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