Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities
- Author
- KURIMOTO, Ayumu1 ; OGINO, Tetsuhiro1 ; ICHII, Shinji1 ; ISOBE, Yoshiaki1 ; TOBE, Masanori1 ; OGITA, Haruhisa1 ; TAKAKU, Haruo1 ; SAJIKI, Hironao1 ; HIROTA, Kosaku2 ; KAWAKAMI, Hajime1
[1] Research Division, Discovery Research Laboratories II, Sumitomo Pharmaceuticals Co. Ltd., Konohana-ku, Osaka 554-0022, Japan
[2] Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, Mitahora-higashi, Gifu 502-8585, Japan - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 5, pp 1091-1099, 9 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antiviral Biodisponibilité Composé bicyclique Ether Hétérocycle azote Immunomodulateur In vitro In vivo Inducteur interféron Pharmacocinétique Plasma sanguin Rat Relation structure activité Souris Splénocyte Synthèse chimique Voie orale Purin-8-ol(6-amino-9-benzyl-2-[2-méthoxyéthoxy]) Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Antiviral Bioavailability Bicyclic compound Ether Nitrogen heterocycle Immunomodulator In vitro In vivo Interferon inducer Pharmacokinetics Blood plasma Rat Structure activity relation Mouse Splenocyte Chemical synthesis Oral administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Antiviral Biodisponibilidad Compuesto bicíclico Eter Heterociclo nitrógeno Inmunomodulador In vitro In vivo Inductor interferón Farmacocinética Plasma sanguíneo Rata Relación estructura actividad Ratón Esplenocito Síntesis química Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02Q Immunomodulators
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15503216
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2003.12.008 
https://dx.doi.org/10.1016/j.bmc.2003.12.008
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