Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase
- Author
- ELDRUP, Anne B1 ; ALLERSON, Charles R1 ; COOK, P. Dan1 ; GETTY, Krista L2 ; MACCOSS, Malcolm3 ; MCMASTERS, Daniel R3 ; OLSEN, David B2 ; PRAKASH, Thazha P1 ; PRHAVC, Marija1 ; SONG, Quanlai1 ; TOMASSINI, Joanne E2 ; JIE XIA1 ; BENNETT, C. Frank1 ; BERA, Sanjib1 ; BHAT, Balkrishen1 ; BHAT, Neelima1 ; BOSSERMAN, Michele R2 ; BROOKS, Jennifer1 ; BURLEIN, Christine2 ; CARROLL, Steven S2
[1] Department of Medicinal Chemistry, Isis Pharmaceuticals, 2280 Faraday Avenue, Carlsbad, California 92008, United States
[2] Department of Biological Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, United States
[3] Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065, United States - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 9, pp 2283-2295, 13 p
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antiviral Composé ramifié In vitro Inhibiteur enzyme Purine nucléoside Purine nucléotide RNA-directed RNA polymerase Relation structure activité Ribonucléoside Réplication Synthèse chimique Virus hépatite C Adénosine(2p-méthyl) Guanosine(2p-méthyl) Enzyme Flaviviridae Hepacivirus Nucleotidyltransferases Transferases Virus
- Keyword (en)
- Antiviral Branched compound In vitro Enzyme inhibitor Purine nucleoside Purine nucleotide RNA-directed RNA polymerase Structure activity relation Ribonucleoside Replication Chemical synthesis Hepatitis C virus Enzyme Flaviviridae Hepacivirus Nucleotidyltransferases Transferases Virus
- Keyword (es)
- Antiviral Compuesto ramificado In vitro Inhibidor enzima Purina nucleósido Purina nucleótido RNA-directed RNA polymerase Relación estructura actividad Ribonucleósido Replicación Síntesis química Hepatitis C virus Enzima Flaviviridae Hepacivirus Nucleotidyltransferases Transferases Virus
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S05 Antiviral agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15684384
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Access to the document
Install on your browser
DOI
10.1021/jm030424e 
https://dx.doi.org/10.1021/jm030424e
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm030424e\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:122:\"Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2004\";s:9:\"\u0000*\u0000volume\";s:2:\"47\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:4:\"2283\";s:8:\"\u0000*\u0000epage\";s:4:\"2295\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"ELDRUP\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Anne B\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:19:{i:0;s:19:\"ALLERSON, Charles R\";i:1;s:12:\"COOK, P. Dan\";i:2;s:15:\"GETTY, Krista L\";i:3;s:16:\"MACCOSS, Malcolm\";i:4;s:19:\"MCMASTERS, Daniel R\";i:5;s:14:\"OLSEN, David B\";i:6;s:17:\"PRAKASH, Thazha P\";i:7;s:14:\"PRHAVC, Marija\";i:8;s:13:\"SONG, Quanlai\";i:9;s:19:\"TOMASSINI, Joanne E\";i:10;s:7:\"JIE XIA\";i:11;s:17:\"BENNETT, C. Frank\";i:12;s:12:\"BERA, Sanjib\";i:13;s:16:\"BHAT, Balkrishen\";i:14;s:13:\"BHAT, Neelima\";i:15;s:20:\"BOSSERMAN, Michele R\";i:16;s:16:\"BROOKS, Jennifer\";i:17;s:18:\"BURLEIN, Christine\";i:18;s:17:\"CARROLL, Steven S\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:122:\"Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Panist access
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm030424e\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:122:\"Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2004\";s:9:\"\u0000*\u0000volume\";s:2:\"47\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:4:\"2283\";s:8:\"\u0000*\u0000epage\";s:4:\"2295\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"ELDRUP\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Anne B\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:19:{i:0;s:19:\"ALLERSON, Charles R\";i:1;s:12:\"COOK, P. Dan\";i:2;s:15:\"GETTY, Krista L\";i:3;s:16:\"MACCOSS, Malcolm\";i:4;s:19:\"MCMASTERS, Daniel R\";i:5;s:14:\"OLSEN, David B\";i:6;s:17:\"PRAKASH, Thazha P\";i:7;s:14:\"PRHAVC, Marija\";i:8;s:13:\"SONG, Quanlai\";i:9;s:19:\"TOMASSINI, Joanne E\";i:10;s:7:\"JIE XIA\";i:11;s:17:\"BENNETT, C. Frank\";i:12;s:12:\"BERA, Sanjib\";i:13;s:16:\"BHAT, Balkrishen\";i:14;s:13:\"BHAT, Neelima\";i:15;s:20:\"BOSSERMAN, Michele R\";i:16;s:16:\"BROOKS, Jennifer\";i:17;s:18:\"BURLEIN, Christine\";i:18;s:17:\"CARROLL, Steven S\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:122:\"Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Istex access
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm030424e\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Unpaywall access
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm030424e\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:122:\"Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2004\";s:9:\"\u0000*\u0000volume\";s:2:\"47\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:4:\"2283\";s:8:\"\u0000*\u0000epage\";s:4:\"2295\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"ELDRUP\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Anne B\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:19:{i:0;s:19:\"ALLERSON, Charles R\";i:1;s:12:\"COOK, P. Dan\";i:2;s:15:\"GETTY, Krista L\";i:3;s:16:\"MACCOSS, Malcolm\";i:4;s:19:\"MCMASTERS, Daniel R\";i:5;s:14:\"OLSEN, David B\";i:6;s:17:\"PRAKASH, Thazha P\";i:7;s:14:\"PRHAVC, Marija\";i:8;s:13:\"SONG, Quanlai\";i:9;s:19:\"TOMASSINI, Joanne E\";i:10;s:7:\"JIE XIA\";i:11;s:17:\"BENNETT, C. Frank\";i:12;s:12:\"BERA, Sanjib\";i:13;s:16:\"BHAT, Balkrishen\";i:14;s:13:\"BHAT, Neelima\";i:15;s:20:\"BOSSERMAN, Michele R\";i:16;s:16:\"BROOKS, Jennifer\";i:17;s:18:\"BURLEIN, Christine\";i:18;s:17:\"CARROLL, Steven S\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:122:\"Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Europe PubMed Central access
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:17:\"10.1021\/jm030424e\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:122:\"Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase\";s:9:\"\u0000*\u0000jtitle\";s:38:\"Journal of medicinal chemistry (Print)\";s:9:\"\u0000*\u0000stitle\";s:21:\"J. med. chem. (Print)\";s:7:\"\u0000*\u0000date\";s:4:\"2004\";s:9:\"\u0000*\u0000volume\";s:2:\"47\";s:8:\"\u0000*\u0000issue\";s:1:\"9\";s:8:\"\u0000*\u0000spage\";s:4:\"2283\";s:8:\"\u0000*\u0000epage\";s:4:\"2295\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0022-2623\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:6:\"ELDRUP\";s:10:\"\u0000*\u0000aufirst\";s:6:\"Anne B\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:19:{i:0;s:19:\"ALLERSON, Charles R\";i:1;s:12:\"COOK, P. Dan\";i:2;s:15:\"GETTY, Krista L\";i:3;s:16:\"MACCOSS, Malcolm\";i:4;s:19:\"MCMASTERS, Daniel R\";i:5;s:14:\"OLSEN, David B\";i:6;s:17:\"PRAKASH, Thazha P\";i:7;s:14:\"PRHAVC, Marija\";i:8;s:13:\"SONG, Quanlai\";i:9;s:19:\"TOMASSINI, Joanne E\";i:10;s:7:\"JIE XIA\";i:11;s:17:\"BENNETT, C. Frank\";i:12;s:12:\"BERA, Sanjib\";i:13;s:16:\"BHAT, Balkrishen\";i:14;s:13:\"BHAT, Neelima\";i:15;s:20:\"BOSSERMAN, Michele R\";i:16;s:16:\"BROOKS, Jennifer\";i:17;s:18:\"BURLEIN, Christine\";i:18;s:17:\"CARROLL, Steven S\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JMCMAR\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:122:\"Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase\";s:8:\"\u0000*\u0000place\";s:14:\"Washington, DC\";s:6:\"\u0000*\u0000pub\";s:25:\"American Chemical Society\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:2:\"13\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
arXiv access
