Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-β type I receptor kinase domain
- Author
- SAWYER, J. Scott1 ; BEIGHT, Douglas W1 ; PARSONS, Stephen1 ; SMITH, Edward C. R1 ; WAGNER, Jill R2 ; LEI YAN3 ; FAMING ZHANG1 ; YINGLING, Jonathan M3 ; BRITT, Karen S2 ; ANDERSON, Bryan D2 ; CAMPBELL, Robert M2 ; GOODSON, Theodore JR1 ; HERRON, David K1 ; LI, Hong-Yu1 ; MCMILLEN, William T1 ; MORT, Nicholas1
[1] Discovery Chemistry Research and Technology, The Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, United States
[2] Lead Optimization Biology, The Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, United States
[3] Cancer Research, The Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 13, pp 3581-3584, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Benzène dérivé Complexe enzyme inhibiteur Composé aromatique Composé bicyclique Diffraction RX Facteur croissance transformant β1 Hétérocycle azote In vitro Inhibiteur enzyme Inhibition Mitogen-activated protein kinase Modèle moléculaire Modélisation Protein kinase Pyridine dérivé Quinoléine dérivé Relation structure activité Récepteur facteur croissance Site fixation Synthèse chimique Sélectivité Transduction signal Pyrrolo[1,2-b]pyrazole dérivé Pyrrolopyrazole Enzyme Transferases
- Keyword (en)
- Benzene derivatives Inhibitor enzyme complex Aromatic compound Bicyclic compound X ray diffraction Transforming growth factor β1 Nitrogen heterocycle In vitro Enzyme inhibitor Inhibition Mitogen-activated protein kinase Molecular model Modeling Protein kinase Pyridine derivatives Quinoline derivatives Structure activity relation Growth factor receptor Binding site Chemical synthesis Selectivity Signal transduction Enzyme Transferases
- Keyword (es)
- Benceno derivado Complejo enzima inhibidor Compuesto aromático Compuesto bicíclico Difracción RX Factor crecimiento transformante β1 Heterociclo nitrógeno In vitro Inhibidor enzima Inhibición Mitogen-activated protein kinase Modelo molecular Modelización Protein kinase Piridina derivado Quinolina derivado Relación estructura actividad Receptor factor crecimiento Sitio fijación Síntesis química Selectividad Transducción señal Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15797333
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.04.007 
https://dx.doi.org/10.1016/j.bmcl.2004.04.007
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