Novel and potent transforming growth factor beta type I receptor kinase domain inhibitor: 7-amino 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-quinolines
- Author
- LI, Hong-Yu1 ; YAN WANG1 ; LEI YAN2 ; CAMPBELL, Robert M3 ; ANDERSON, Bryan D3 ; WAGNER, Jill R3 ; YINGLING, Jonathan M2
[1] Discovery Chemistry Research, Lilly Research Laboratory, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States
[2] Cancer Research, Lilly Research Laboratory, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States
[3] Lead Optimization Biology, Lilly Research Laboratory, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 13, pp 3585-3588, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Composé aromatique Composé bicyclique Facteur croissance transformant β1 Fibroblaste Hétérocycle azote In vitro Inhibiteur enzyme Inhibition Lignée cellulaire Mitogen-activated protein kinase Protein kinase Pyridine dérivé Quinoléine dérivé Relation structure activité Récepteur facteur croissance Souris Synthèse chimique Transduction signal Bras espaceur Lignée NIH3T3 Lignée p3TP Pyrrolo[1,2-b]pyrazole dérivé Pyrrolopyrazole Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Animal Aromatic compound Bicyclic compound Transforming growth factor β1 Fibroblast Nitrogen heterocycle In vitro Enzyme inhibitor Inhibition Cell line Mitogen-activated protein kinase Protein kinase Pyridine derivatives Quinoline derivatives Structure activity relation Growth factor receptor Mouse Chemical synthesis Signal transduction Spacer arm Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Animal Compuesto aromático Compuesto bicíclico Factor crecimiento transformante β1 Fibroblasto Heterociclo nitrógeno In vitro Inhibidor enzima Inhibición Línea celular Mitogen-activated protein kinase Protein kinase Piridina derivado Quinolina derivado Relación estructura actividad Receptor factor crecimiento Ratón Síntesis química Transducción señal Enzima Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15797334
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.04.065 
https://dx.doi.org/10.1016/j.bmcl.2004.04.065
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