Synthesis and evaluation of 6-methylene-bridged uracil derivatives. Part 2: Optimization of inhibitors of human thymidine phosphorylase and their selectivity with uridine phosphorylase
- Author
- YANO, Shingo1 ; KAZUNO, Hideki1 ; ASAO, Tetsuji1 ; SATO, Tsutomu1 ; SUZUKI, Norihiko1 ; EMURA, Tomohiro1 ; WIERZBA, Konstanty1 ; YAMASHITA, Jun-Ichi1 ; TADA, Yukio1 ; YAMADA, Yuji1 ; FUKUSHIMA, Masakazu1
[1] Hanno Research Center, Taiho Pharmaceutical Co., Ltd, 1-27 Misugidai, Hanno-shi, Saitama 357-8527, Japan - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 13, pp 3443-3450, 8 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Amidine Animal Anticancéreux Biodisponibilité Homme In vitro In vivo Inhibiteur enzyme Pharmacocinétique Pyrimidine dérivé Pyrrolidine dérivé Rat Relation structure activité Souris Synthèse chimique Sélectivité Thymidine phosphorylase Uridine phosphorylase Voie orale Uracile(5-bromo-6-[2-iminopyrrolidino]) chlorhydrate Enzyme Glycosyltransferases Halogène Composé organique Mammalia Pentosyltransferases Rodentia Transferases Vertebrata
- Keyword (en)
- Amidine Animal Antineoplastic agent Bioavailability Human In vitro In vivo Enzyme inhibitor Pharmacokinetics Pyrimidine derivatives Pyrrolidine derivatives Rat Structure activity relation Mouse Chemical synthesis Selectivity Thymidine phosphorylase Uridine phosphorylase Oral administration Enzyme Glycosyltransferases Halogen Organic compounds Mammalia Pentosyltransferases Rodentia Transferases Vertebrata
- Keyword (es)
- Amidina Animal Anticanceroso Biodisponibilidad Hombre In vitro In vivo Inhibidor enzima Farmacocinética Pirimidina derivado Rata Relación estructura actividad Ratón Síntesis química Selectividad Thymidine phosphorylase Uridine phosphorylase Vía oral Enzima Glycosyltransferases Halógeno Compuesto orgánico Mammalia Pentosyltransferases Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15859684
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.04.046 
https://dx.doi.org/10.1016/j.bmc.2004.04.046
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