Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N, N-dimethylaminoethyl)dibenzo[c, h][1,6]-naphthyridin-6-on es: influence on topoisomerase I-targeting activity and cytotoxicity
- Author
- RUCHELMAN, Alexander L1 ; KERRIGAN, John E2 3 ; LI, Tsai-Kun2 ; NAI ZHOU2 ; LIU, Angela2 ; LIU, Leroy F2 3 ; LAVOIE, Edmond J1 3
[1] Department of Pharmaceutical Chemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8020, United States
[2] Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, NJ 08854, United States
[3] Cancer Institute of New Jersey, New Brunswick, NJ 08901, United States - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 13, pp 3731-3742, 12 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité enzymatique Amine aromatique Amine tertiaire Animal Anticancéreux Cellule tumorale Clivage Composé aromatique Composé nitro Composé tétracyclique Cytotoxicité DNA topoisomerase DNA Diéther Homme Hétérocycle azote In vitro Lactame Leucémie P388 Lignée cellulaire Mécanisme action Relation structure activité Scission Souris Synthèse chimique Dibenzo[c,h][1,6]naphtyridin-6-one dérivé Dibenzonaphtyridine Lignée CPTK5 Lignée RPMI8402 Enzyme Isomerases Mammalia Rodentia Vertebrata
- Keyword (en)
- Enzymatic activity Aromatic amine Tertiary amine Animal Antineoplastic agent Tumor cell Cleavage Aromatic compound Nitro compound Tetracyclic compound Cytotoxicity DNA topoisomerase DNA Diether Human Nitrogen heterocycle In vitro Lactam P388-Leukemia Cell line Mechanism of action Structure activity relation Scission Mouse Chemical synthesis Enzyme Isomerases Mammalia Rodentia Vertebrata
- Keyword (es)
- Actividad enzimática Amina aromática Amina terciaria Animal Anticanceroso Célula tumoral Clivaje Compuesto aromático Compuesto nitro Compuesto tetracíclico Citotoxicidad DNA topoisomerase DNA Dieter Hombre Heterociclo nitrógeno In vitro Lactamo Leucemia P388 Línea celular Mecanismo acción Relación estructura actividad Escisión Ratón Síntesis química Enzima Isomerases Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15859713
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.03.076 
https://dx.doi.org/10.1016/j.bmc.2004.03.076
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