Novel pyridazino[4,3-b]indoles with dual inhibitory activity against Mycobacterium tuberculosis and monoamine oxidase
- Author
- VELEZHEVA, Valeriya S1 ; BRENNAN, Patrick J2 ; MARSHAKOV, Vladimir Yu1 ; GUSEV, Dmitrij V1 ; LISICHKINA, Inessa N1 ; PEREGUDOV, Alexander S1 ; TCHERNOUSOVA, Larisa N3 ; SMIRNOVA, Tatiana G3 ; ANDREEVSKAYA, Sofia N3 ; MEDVEDEV, Alexei E4
[1] A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilov Street, 119991 Moscow, Russian Federation
[2] Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, United States
[3] Central TB Research Institute, Russian Academy of Medical Sciences, 2 Yauzskaya Alley, 107564 Moscow, Russian Federation
[4] Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, 10 Pogodinskaya Street, 119832 Moscow, Russian Federation - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 13, pp 3455-3461, 7 p ; ref : 39 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- Russian
- Keyword (fr)
- Amine oxidase (flavin-containing) Animal Antibactérien Antituberculeux Benzène dérivé Composé aromatique Composé tricyclique Foie Hétérocycle azote IMAO In vitro Inhibiteur enzyme Mitochondrie Mycobacterium tuberculosis Rat Relation structure activité Synthèse chimique Pyridazino[4,3-b]indol-3-one dérivé Pyridazino[4,3-b]indole dérivé Pyridazinoindole Actinomycetes Bactérie Enzyme Mammalia Mycobacteriaceae Mycobacteriales Oxidoreductases Rodentia Vertebrata
- Keyword (en)
- Amine oxidase (flavin-containing) Animal Antibacterial agent Antituberculous agent Benzene derivatives Aromatic compound Tricyclic compound Liver Nitrogen heterocycle MAO inhibitor In vitro Enzyme inhibitor Mitochondria Mycobacterium tuberculosis Rat Structure activity relation Chemical synthesis Actinomycetes Bacteria Enzyme Mammalia Mycobacteriaceae Mycobacteriales Oxidoreductases Rodentia Vertebrata
- Keyword (es)
- Amine oxidase (flavin-containing) Animal Antibacteriano Antituberculoso Benceno derivado Compuesto aromático Compuesto tricíclico Hígado Heterociclo nitrógeno IMAO In vitro Inhibidor enzima Mitocondria Mycobacterium tuberculosis Rata Relación estructura actividad Síntesis química Actinomycetes Bacteria Enzima Mammalia Mycobacteriaceae Mycobacteriales Oxidoreductases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S02 Antibacterial agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15860464
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm030479g 
https://dx.doi.org/10.1021/jm030479g
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