Development and validation of a gas chromatography-mass spectrometry method for the simultaneous determination of buprenorphine, flunitrazepam and their metabolites in rat plasma: application to the pharmacokinetic study
- Author
- PIMAY, Stephane1 2 ; BOUCHONNET, Stephane3 ; HERVE, Francoise2 ; LIBONG, Danielle3 ; MILAN, Nathalie1 ; D'ATHIS, Philippe4 ; BAUD, Frédéric2 ; RICORDEL, Ivan1
[1] Laboratoire de Toxicologie de la Préfecture de Police, 2 Place Mazas, 75012 Paris, France
[2] INSERM U26, Hôpital Fernand Widal, 200 rue du Faubourg Saint-Denis, 75475 Paris, France
[3] Département de Chimie des Mécanismes Réactionnels, Ecole Polytechnique, Route de Saclay, 91128 Palaiseau, France
[4] Service de Biostatistique et Informatique Médicale, Centre Hospitalier Universitaire de Dijon, 21034 Dijon, France - Source
Journal of chromatography. B. 2004, Vol 807, Num 2, pp 335-342, 8 p ; ref : 41 ref
- ISSN
- 1570-0232
- Scientific domain
- Medical laboratory techniques; Pharmacology drugs
- Publisher
- Elsevier Science, Amsterdam
- Publication country
- Netherlands
- Document type
- Article
- Language
- English
- Keyword (fr)
- Analgésique narcotique Animal Benzodiazépine dérivé Buprénorphine Chromatographie phase gazeuse Développement Etat dépressif Flunitrazépam Liquide biologique Mesure simultanée Mort Métabolite Pharmacocinétique Plasma sanguin Rat Spectrométrie Technique SIM Mammalia Opiacés Rodentia Trouble humeur Vertebrata
- Keyword (en)
- Narcotic analgesic Animal Benzodiazepine derivatives Buprenorphine Gas chromatography Development Depression Flunitrazepam Biological fluid Simultaneous measurement Death Metabolite Pharmacokinetics Blood plasma Rat Spectrometry Mammalia Opiates Rodentia Mood disorder Vertebrata
- Keyword (es)
- Analgésico narcotico Animal Benzodiazepina derivado Buprenorfina Cromatografía fase gaseosa Desarrollo Estado depresivo Flunitrazepam Líquido biológico Medición simultánea Muerte Metabolito Farmacocinética Plasma sanguíneo Rata Espectrometría Mammalia Opiados Rodentia Trastorno humor Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A02 Analysis
- Discipline
- Analytical, structural and metabolic biochemistry General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15870159
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.jchromb.2004.04.029 
https://dx.doi.org/10.1016/j.jchromb.2004.04.029
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