Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine
- Author
- PRADO, Soizic1 ; MICHEL, Sylvie1 ; BAILLY, Christian5 ; TILLEQUIN, Francois1 ; KOCH, Michel1 ; PFEIFFER, Bruno2 ; PIERRE, Alain3 ; LEONCE, Stéphane3 ; COLSON, Pierre4 ; BALDEYROU, Brigitte5 ; LANSIAUX, Amélie5
[1] Laboratoire de Pharmacognosie de l'Université René Descartes, UMR/CNRS No. 8638, Faculté des Sciences Pharmaceutiques et Biologiques, 4 Avenue de l'Observatoire, 75006 Paris, France
[2] Les Laboratoires Servier, 1 rue Carle Hebert, 92415 Courbevoie, France
[3] Institut de Recherches Servier, Division Recherche Cancérologie, 125 Chemin de Ronde, 78290 Croissy sur Seine, France
[4] Biospectroscopy and Physical Chemistry Unit, Department of Chemistry and Natural and Synthetic Drugs Research Center, University of Liège, Sart-Tilman, 4000 Liège, Belgium
[5] INSERM U-524 et Laboratoire de Pharmacologie Antitumorale du Centre Oscar Lambret, IRCL, 59045 Lille, France - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 14, pp 3943-3953, 11 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Agent intercalant Animal Anticancéreux Cellule tumorale Composé aromatique Composé pentacyclique Composé tétracyclique Cytotoxicité DNA topoisomerase DNA Fixation biologique Hétérocycle azote Hétérocycle oxygène azote In vitro Inhibiteur enzyme Interaction moléculaire Isomère position Lignée L1210 Lignée cellulaire Relation structure activité Souris Synthèse chimique Benzo[c][1,7]phénanthroline dérivé Benzo[c][1,8]phénanthroline dérivé Benzophénanthroline Enzyme Isomerases Mammalia Rodentia Vertebrata
- Keyword (en)
- Intercalating agent Animal Antineoplastic agent Tumor cell Aromatic compound Pentacyclic compound Tetracyclic compound Cytotoxicity DNA topoisomerase DNA Biological fixation Nitrogen heterocycle Oxygen nitrogen heterocycle In vitro Enzyme inhibitor Molecular interaction Position isomer L1210 cell line Cell line Structure activity relation Mouse Chemical synthesis Enzyme Isomerases Mammalia Rodentia Vertebrata
- Keyword (es)
- Agente intercalante Animal Anticanceroso Célula tumoral Compuesto aromático Compuesto pentacíclico Compuesto tetracíclico Citotoxicidad DNA topoisomerase DNA Fijación biológica Heterociclo nitrógeno Heterociclo oxígeno nitrógeno In vitro Inhibidor enzima Interacción molecular Isómero posición Célula L1210 Línea celular Relación estructura actividad Ratón Síntesis química Enzima Isomerases Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15888784
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.04.038 
https://dx.doi.org/10.1016/j.bmc.2004.04.038
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