Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors
- Author
- MORRELL, Andrew1 ; ANTONY, Smitha2 ; KOHLHAGEN, Glenda2 ; POMMIER, Yves2 ; CUSHMAN, Mark1
[1] Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907, United States
[2] Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4255, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 14, pp 3659-3663, 5 p ; ref : 14 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Cellule tumorale Composé aromatique Composé nitro Composé tétracyclique Cytotoxicité DNA topoisomerase Hétérocycle azote In vitro Inhibiteur enzyme Lignée cellulaire Relation structure activité Synthèse chimique Indénoisoquinoléine Enzyme Isomerases
- Keyword (en)
- Antineoplastic agent Tumor cell Aromatic compound Nitro compound Tetracyclic compound Cytotoxicity DNA topoisomerase Nitrogen heterocycle In vitro Enzyme inhibitor Cell line Structure activity relation Chemical synthesis Enzyme Isomerases
- Keyword (es)
- Anticanceroso Célula tumoral Compuesto aromático Compuesto nitro Compuesto tetracíclico Citotoxicidad DNA topoisomerase Heterociclo nitrógeno In vitro Inhibidor enzima Línea celular Relación estructura actividad Síntesis química Enzima Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15889606
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.05.022 
https://dx.doi.org/10.1016/j.bmcl.2004.05.022
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