Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the α3β4* nicotinic acetylcholine receptors through modifications to the ester
- Author
- BERGMEIER, Stephen C1 ; ISMAIL, Khadiga A2 ; ARASON, Kristjan M1 ; MCKAY, Susan3 ; BRYANT, Darrell L3 ; MCKAY, Dennis B3
[1] Department of Chemistry and Biochemistry, Ohio University, Athens, OH 45701, United States
[2] Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt
[3] Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 14, pp 3739-3742, 4 p ; ref : 39 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Alcaloïde Aminoalcool Antagoniste Composé polycyclique Diterpène Hétérocycle azote In vitro Neurone Relation structure activité Récepteur cholinergique Récepteur nicotinique Synthèse chimique Système nerveux Sélectivité Terpénoïde Aconitane dérivé lycaconitine dérivé
- Keyword (en)
- Affinity Alkaloid Aminoalcohol Antagonist Polycyclic compound Diterpene Nitrogen heterocycle In vitro Neuron Structure activity relation Cholinergic receptor Nicotinic receptor Chemical synthesis Nervous system Selectivity Terpenoid
- Keyword (es)
- Afinidad Alcaloide Aminoalcohol Antagonista Compuesto policíclico Diterpeno Heterociclo nitrógeno In vitro Neurona Relación estructura actividad Receptor colinérgico Receptor nicotínico Síntesis química Sistema nervioso Selectividad Terpenoide
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09B Cholinergic system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15889621
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.05.001 
https://dx.doi.org/10.1016/j.bmcl.2004.05.001
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