Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production
- Author
- DE MENTHIERE, Cyril Sarrauste1 ; CHAVANIEU, Alain1 ; BAKES, David5 ; KTORZA, Alain6 ; CALAS, Bernard1 ; GRASSY, Gérard1 ; DALLE, Stéphane2 ; SALAZAR, Guillermo2 ; KERVRAN, Alain2 ; PFEIFFER, Bruno3 ; RENARD, Pierre3 ; DELAGRANGE, Philippe4 ; MANECHEZ, Dominique4
[1] Centre de Biochimie Structurale, CNRS UMR 5048 - UMI - INSERM UMR 554, 29 rue de Navacelles, 34090 Montpellier, France
[2] INSERM U-376. CHU Arnaud de Villeneuve, 34295 Montpellier, France
[3] ADIR, 1 rue Carle Hébert, 92415 Courbevoie, France
[4] Institut de Recherches Internationales Servier, 6 Place des Pléiades, 92415 Courbevoie, France
[5] Servier Research and Development, Fulmer Hall, Windmill Road, Fulmer, Slough SL3 6HH, United Kingdom
[6] Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Université Paris, 2 Place Jussieu, 75251 Paris, France - Source
European journal of medicinal chemistry. 2004, Vol 39, Num 6, pp 473-480, 8 p ; ref : 28 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Circular dichroism Conformations Glucagon-Like Peptide-1 Glucose tolerance test Plasma stability Structure-activity relationships
- Keyword (fr)
- AMP cyclique Affinité Agoniste Animal Chimiothérapie Conformation Diabète type 2 Dichroïsme circulaire Homme Hormone gastrointestinale Hyperglycémie provoquée In vitro In vivo Modèle moléculaire Modélisation Peptide GLP1 Peptide Plasma sanguin Polypeptide Rat Relation structure activité Récepteur hormonal Résistance hydrolyse Souris Synthèse chimique Synthèse peptidique Traitement Voie intraveineuse Mammalia Rodentia Vertebrata
- Keyword (en)
- Cyclic AMP Affinity Agonist Animal Chemotherapy Conformation Type 2 diabetes Circular dichroism Human Gastrointestinal hormone Glucose tolerance test In vitro In vivo Molecular model Modeling Glucagon like peptide 1 Peptides Blood plasma Polypeptide Rat Structure activity relation Hormonal receptor Hydrolysis resistance Mouse Chemical synthesis Peptide synthesis Treatment Intravenous administration Mammalia Rodentia Vertebrata
- Keyword (es)
- AMP cíclico Afinidad Agonista Animal Quimioterapia Conformación Diabetes de tipo 2 Dicroismo circular Hombre Hormona gastrointestinal Hiperglicemia provocada In vitro In vivo Modelo molecular Modelización Péptido GLP1 Péptido Plasma sanguíneo Polipéptido Rata Relación estructura actividad Receptor hormonal Resistencia hidrólisis Ratón Síntesis química Síntesis peptídica Tratamiento Vía intravenosa Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02O Hormones. Endocrine system
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15904188
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2004.02.002 
https://dx.doi.org/10.1016/j.ejmech.2004.02.002
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