Synthesis and cytotoxic activity of substituted 7-aryliminomethyl derivatives of camptothecin
- Author
- DALLAVALLE, Sabrina1 ; MERLINI, Lucio1 ; MORINI, Gabriella1 ; MUSSO, Loana1 ; PENCO, Sergio2 ; BERETTA, Giovanni Luca3 ; TINELLI, Stella3 ; ZUNINO, Franco3
[1] Dipartimento di Scienze Molecolari Agroalimentari, Sezione di Chimica, Università di Milano, Via Celoria 2, 20133 Milan, Italy
[2] R&D, Sigma-Tau, Pomezia, Italy
[3] Dipartimento di Farmacologia Preclinica, Istituto Nazionale per le Studio e la Cura dei Tumori, Via Venezian, 20133 Milan, Italy - Source
European journal of medicinal chemistry. 2004, Vol 39, Num 6, pp 507-513, 7 p ; ref : 17 ref
- CODEN
- EJMCA5
- ISSN
- 0223-5234
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Antitumour Camptothecin Imines Topoisomerase
- Keyword (fr)
- Activité enzymatique Alcaloïde Anticancéreux Benzène dérivé Cellule tumorale Clivage Composé aromatique Composé pentacyclique Cytotoxicité DNA topoisomerase DNA Homme Hydrazone Hétérocycle oxygène azote In vitro Lactame Lactone Lignée cellulaire Modèle 3 dimensions Modèle moléculaire Modélisation Relation structure activité Scission Site clivage Synthèse chimique Camptothécine dérivé Lignée H460 Enzyme Isomerases
- Keyword (en)
- Enzymatic activity Alkaloid Antineoplastic agent Benzene derivatives Tumor cell Cleavage Aromatic compound Pentacyclic compound Cytotoxicity DNA topoisomerase DNA Human Hydrazone Oxygen nitrogen heterocycle In vitro Lactam Lactone Cell line Three dimensional model Molecular model Modeling Structure activity relation Scission Cleavage site Chemical synthesis Enzyme Isomerases
- Keyword (es)
- Actividad enzimática Alcaloide Anticanceroso Benceno derivado Célula tumoral Clivaje Compuesto aromático Compuesto pentacíclico Citotoxicidad DNA topoisomerase DNA Hombre Hidrazona Heterociclo oxígeno nitrógeno In vitro Lactamo Lactona Línea celular Modelo 3 dimensiones Modelo molecular Modelización Relación estructura actividad Escisión Sitio clivaje Síntesis química Enzima Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15904192
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.ejmech.2004.02.011 
https://dx.doi.org/10.1016/j.ejmech.2004.02.011
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