Synthesis and structure-activity relationships of novel IKK-β inhibitors. Part 2: Improvement of in vitro activity
- Author
- MURATA, Toshiki1 ; SHIMADA, Mitsuyuki1 ; ZIEGELBAUER, Karl B2 ; LOWINGER, Timothy B1 ; KADONO, Hiroshi1 ; SAKAKIBARA, Sachiko1 ; YOSHINO, Takashi1 ; MASUDA, Tsutomu1 ; SHIMAZAKI, Makoto1 ; SHINTANI, Takuya1 ; FUCHIKAMI, Kinji2 ; BACON, Kevin B2
[1] Department of Chemistry, Research Center Kyoto, Bayer Yakuhin, Ltd, Kizu, Soraku, Kyoto 619-0216, Japan
[2] Department of Biology, Research Center Kyoto, Bsyer Yakuhin, Ltd, Kizu, Soraku, Kyoto 619-0216, Japan - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 15, pp 4013-4017, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Composé aromatique Facteur transcription NFκB In vitro Inhibiteur enzyme Kinase Nitrile Protein kinase Pyridine dérivé Relation structure activité Synthèse chimique Transduction signal Protein kinase IκB Enzyme Transferases
- Keyword (en)
- Aromatic compound Transcription factor NFκB In vitro Enzyme inhibitor Kinase Nitrile Protein kinase Pyridine derivatives Structure activity relation Chemical synthesis Signal transduction Enzyme Transferases
- Keyword (es)
- Compuesto aromático Factor transcripción NFκB In vitro Inhibidor enzima Kinase Nitrilo Protein kinase Piridina derivado Relación estructura actividad Síntesis química Transducción señal Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15919321
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.05.040 
https://dx.doi.org/10.1016/j.bmcl.2004.05.040
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