New broad-spectrum parenteral cephalosporins exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Part 2: Synthesis and structure-activity relationships in the S-3578 series
- Author
- YOSHIZAWA, Hidenori1 ; KUBOTA, Tadatoshi1 ; ITANI, Hikaru1 ; ISHITOBI, Hiroyuki1 ; MIWA, Hideaki1 ; NISHITANI, Yasuhiro1
[1] Shionogi Research Laboratories, Shionogi & Co., Ltd, 12-4, Sagisu 5-chome, Fukushima-ku, Osaka 553-0002, Japan - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 15, pp 4211-4219, 9 p ; ref : 6 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antibactérien Carboxylate Cation organique Céphalosporine dérivé Hydrosolubilité Iminium composé Méticilline Pseudomonas aeruginosa Relation structure activité Résistance Staphylococcus aureus Synthèse chimique Thiadiazole dérivé 5-Thia-1-azabicyclo[4.2.0]oct-2-ène dérivé Céphème dérivé Pyrazolo[4,3-b]pyridinium composé Pyrazolopyridinium Souche résistante méticilline Bactérie Micrococcaceae Micrococcales Pseudomonadaceae Pseudomonadales
- Keyword (en)
- Antibacterial agent Carboxylate Organic cation Cephalosporin derivatives Water solubility Iminium compounds Meticillin Pseudomonas aeruginosa Structure activity relation Resistance Staphylococcus aureus Chemical synthesis Thiadiazole derivatives Bacteria Micrococcaceae Micrococcales Pseudomonadaceae Pseudomonadales
- Keyword (es)
- Antibacteriano Carboxilato Catión orgánico Cefalosporina derivado Hidrosolubilidad Iminio compuesto Meticilina Pseudomonas aeruginosa Relación estructura actividad Resistencia Staphylococcus aureus Síntesis química Tiadiazol derivado Bacteria Micrococcaceae Micrococcales Pseudomonadaceae Pseudomonadales
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02S Antibiotics. Antiinfectious agents. Antiparasitic agents / 002B02S02 Antibacterial agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15950845
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.05.022 
https://dx.doi.org/10.1016/j.bmc.2004.05.022
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