Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX2R) antagonists
- Author
- MCATEE, Laura C1 ; SUTTON, Steven W1 ; RUDOLPH, Dale A1 ; XIAOBING LI1 ; ALUISIO, Leah E1 ; PHUONG, Victor K1 ; DVORAK, Curt A1 ; LOVENBERG, Timothy W1 ; CARRUTHERS, Nicholas I1 ; JONES, Todd K1
[1] Johnson and Johnson Pharmaceutical Research and Development, LLC, 3210, Merryfield Row, San Diego, CA 92121, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 16, pp 4225-4229, 5 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Affinité Antagoniste Benzène dérivé Cycle 6 chaînons Hétérocycle oxygène In vitro Neuropeptide Orexine Protéine G Relation structure activité Récepteur peptidergique Synthèse chimique 1,3-Dioxane dérivé Récepteur orexine Urée(1-[2,4-dibromophényl]-3-[2,2-diméthyl-4-phényl-1,3-dioxan-5-yl]) Brome Composé organique
- Keyword (en)
- Affinity Antagonist Benzene derivatives Six membered ring Oxygen heterocycle In vitro Neuropeptide Orexin G protein Structure activity relation Peptidergic receptor Chemical synthesis Orexin receptor Bromine Organic compounds
- Keyword (es)
- Afinidad Antagonista Benceno derivado Ciclo 6 eslabones Heterociclo oxígeno In vitro Neuropéptido Orexina Proteína G Relación estructura actividad Receptor peptidérgico Síntesis química Bromo Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09F Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15956307
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.06.032 
https://dx.doi.org/10.1016/j.bmcl.2004.06.032
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