Substituted 3-Imidazo[1,2-a]pyridin-3-yl-4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indo l-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3
- Author
- ENGLER, Thomas A1 ; HENRY, James R1 ; HAWKINS, Eric1 ; IVERSEN, Philip W1 ; YIHONG LI1 ; LINDSTROM, Terry D1 ; MARQUART, Angela L1 ; MCLEAN, Johnathan1 ; MENDEL, David1 ; MISENER, Elizabeth1 ; BRIERE, Daniel1 ; O, John C1 ; MALHOTRA, Sushant1 ; TOOLE2 ; PORTER, Warren J2 ; QUEENER, Steven2 ; REEL, Jon K2 ; OWENS, Rebecca A2 ; BRIER, Richard A2 ; EESSALU, Thomas E2 ; WAGNER, Jill R2 ; CAMPBELL, Robert M2 ; VAUGHN, Renee2 ; CUNNINGHAM, Brian1 ; FURNESS, Kelly1 ; BROZINICK, Joseph1 ; BURKHOLDER, Timothy P1 ; CLAY, Michael P1 ; CLAYTON, Joshua1 ; DIEFENBACHER, Clive1
[1] Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States
[2] Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, United States - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 16, pp 3934-3937, 4 p ; ref : 25 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Biodisponibilité Carbamate organique Composé bicyclique Composé tricyclique Cycle 5 chaînons Diabète type 2 Hypoglycémiant Hétérocycle azote angulaire Imide In vitro In vivo Inhibiteur enzyme Morpholine dérivé Pharmacocinétique Pipéridine dérivé Protein kinase Rat Relation structure activité Synthèse chimique Sélectivité Traitement Transduction signal Urées Voie intraveineuse Voie orale Glycogen synthase kinase Imidazo[1,2-a]pyridine dérivé Imidazopyridine Maléimide dérivé Pyrrolo[3,2,1-jk][1,4]benzodiazépine-2-carboxylique acide dérivé Pyrrolobenzodiazépine Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (en)
- Animal Bioavailability Organic carbamate Bicyclic compound Tricyclic compound Five membered ring Type 2 diabetes Hypoglycemic agent Angular nitrogen heterocycle Imide In vitro In vivo Enzyme inhibitor Morpholine derivatives Pharmacokinetics Piperidine derivatives Protein kinase Rat Structure activity relation Chemical synthesis Selectivity Treatment Signal transduction Ureas Intravenous administration Oral administration Enzyme Mammalia Rodentia Transferases Vertebrata
- Keyword (es)
- Animal Biodisponibilidad Carbamato orgánico Compuesto bicíclico Compuesto tricíclico Ciclo 5 eslabones Diabetes de tipo 2 Hipoglicemiante Heterociclo nitrógeno angular Imida In vitro In vivo Inhibidor enzima Farmacocinética Piperidina derivado Protein kinase Rata Relación estructura actividad Síntesis química Selectividad Tratamiento Transducción señal Ureas Vía intravenosa Vía oral Enzima Mammalia Rodentia Transferases Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02N General and cellular metabolism. Vitamins
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 15965959
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049768a 
https://dx.doi.org/10.1021/jm049768a
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