Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides
- Author
- MITSCH, Andreas1 ; WISSNER, Pia1 ; SILBER, Katrin1 ; HAEBEL, Peter1 ; SATTLER, Isabel2 ; KLEBE, Gerhard1 ; SCHLITZER, Martin3
[1] Institut far Pharmazeutische Chemie, Philipps-Universität Marburg, Marbacher Weg 6, 35032 Marburg, Germany
[2] Hans-Knöll-Intitut für Naturstoff-Forschung e. V., Beutenbergstrasse 11, 07745 Jena, Germany
[3] Department für Pharmazie-Zentrum far Pharmaforschung, Ludwig-Maximilians-Universitat München, Butenandtstrasse 5-13, 81377 München, Germany - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 17, pp 4585-4600, 16 p ; ref : 31 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Benzophénone dérivé Benzène dérivé Carboxamide Composé vinylique Cycle 5 chaînons Farnesyl-diphosphate farnesyltransferase Hétérocycle oxygène In vitro Inhibiteur enzyme Modèle moléculaire Modélisation Relation structure activité Site fixation Synthèse chimique Furane-2-acrylamide(N-[3-benzoyl-4-(p-tolylacétamido)phényl]-5-p-tolyl) Enzyme Transferases
- Keyword (en)
- Benzophenone derivatives Benzene derivatives Carboxamide Vinylic compound Five membered ring Farnesyl-diphosphate farnesyltransferase Oxygen heterocycle In vitro Enzyme inhibitor Molecular model Modeling Structure activity relation Binding site Chemical synthesis Enzyme Transferases
- Keyword (es)
- Benzofenona derivado Benceno derivado Carboxamida Compuesto vinílico Ciclo 5 eslabones Farnesyl-diphosphate farnesyltransferase Heterociclo oxígeno In vitro Inhibidor enzima Modelo molecular Modelización Relación estructura actividad Sitio fijación Síntesis química Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16017798
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.07.010 
https://dx.doi.org/10.1016/j.bmc.2004.07.010
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