Structural basis for the binding of didemnins to human elongation factor eEF1A and rationale for the potent antitumor activity of these marine natural products
- Author
- MARCO, Esther; MARTIN-SANTAMARIA, Sonsoles; CUEVAS, Carmen; GAGO, Federico
Departamento de Farmacología, Universidad de Alcalá, 28871 Alcalâ de Henares, Madrid, Spain
Pharma Mar S.A., Avda. de los Reyes, 1 Polígono Industrial La Mina, 28770 Colmenar Viejo, Madrid, Spain - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 18, pp 4439-4452, 14 p ; ref : 80 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Anticancéreux Conformation Depsipeptide Facteur élongation EF1 Fixation biologique GTP Interaction électrostatique Milieu marin Modèle moléculaire Modélisation Mécanisme action Méthode dynamique moléculaire Peptide cyclique Didemnine dérivé Tamandarine dérivé
- Keyword (en)
- Biological activity Antineoplastic agent Conformation Depsipeptide Elongation factor EF1 Biological fixation GTP Electrostatic interaction Marine environment Molecular model Modeling Mechanism of action Molecular dynamics method Cyclic peptides
- Keyword (es)
- Actividad biológica Anticanceroso Conformación Depsipéptido Factor elongación EF1 Fijación biológica GTP Interacción electrostática Medio marino Modelo molecular Modelización Mecanismo acción Método dinámico molecular Péptido cíclico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16040965
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0306428 
https://dx.doi.org/10.1021/jm0306428
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