Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective tgf-β type I receptor inhibitors
- Author
- GELLIBERT, Francoise; WOOLVEN, James; JANSON, Cheryl; SMITH, Ward; KRYSA, Gaël; BOULLAY, Valérie; DE GOUVILLE, Anne-Charlotte; HUET, Stéphane; HARTLEY, David; FOUCHET, Marie-Hélène; MATHEWS, Neil; GOODLAND, Helen; LOVEGROVE, Victoria; LAROZE, Alain; NGUYEN, Van-Loc; SAUTET, Stéphane; RUOLAN WANG
Departments of Medicinal Chemistry and Biology, GlaxoSmithKline, 25-27 Avenue du Québec, 91951 Les Ulis, France
Discovery Research, Assay Development and Compound Profiling, GlaxoSmithKline, Five Moore Drive, P.O. Box 13398, Research Triangle Park, North Carolina 27709, United States
Discovery Research, Computational and Structural Science, and Department of Medicinal Chemistry, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
Discovery Research, GlaxoSmithKline, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 18, pp 4494-4506, 13 p ; ref : 25 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Autophosphorylation Cytokine Facteur croissance transformant β Hétérocycle azote Hétérocycle soufre azote Inhibiteur Mode liaison Naphtyridine dérivé Protein kinase Pyrazole dérivé Pyridine dérivé Relation structure activité Récepteur biologique Synthèse chimique Sélectivité Thiazole dérivé Transduction signal 1,5-Naphtyridine(2-[2-amino-4-(6-méthyl-2-pyridyl)thiazol-5-yl]) Enzyme Transferases
- Keyword (en)
- Autophosphorylation Cytokine Transforming growth factor β Nitrogen heterocycle Sulfur nitrogen heterocycle Inhibitor Binding mode Naphtyridine derivatives Protein kinase Pyrazole derivatives Pyridine derivatives Structure activity relation Biological receptor Chemical synthesis Selectivity Thiazole derivatives Signal transduction Enzyme Transferases
- Keyword (es)
- Autofosforilación Citoquina Factor crecimiento transformante β Heterociclo nitrógeno Heterociclo azufre nitrógeno Inhibidor Modo de enlace Protein kinase Pirazol derivado Piridina derivado Relación estructura actividad Receptor biológico Síntesis química Selectividad Tiazol derivado Transducción señal Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16040970
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0400247 
https://dx.doi.org/10.1021/jm0400247
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