Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists
- Author
- NAKAZATO, Atsuro; SAKAGAMI, Kazunari; YASUHARA, Akito; OHTA, Hiroshi; YOSHIKAWA, Ryoko; ITOH, Manabu; NAKAMURA, Masato; CHAKI, Shigeyuki
Medicinal Chemistry Laboratory, Medicinal Pharmacology Laboratory, and Drug Metabolism Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 18, pp 4570-4587, 18 p ; ref : 42 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Absorption Aminoacide Antagoniste Chlore composé organique Composé bicyclique Diacide carboxylique Enantiomère(-) Fluor composé organique In vitro Pharmacocinétique Pénétration Relation structure activité Récepteur glutamate mglu groupe II Synthèse chimique Système nerveux central Sélectivité Voie orale Bicyclo[3.1.O]hexane-2,6-dicarboxylique acide(2-amino-3-[3,4-dichlorobenzyloxy]-6-fluoro) MGS 0039
- Keyword (en)
- Absorption Aminoacid Antagonist Organic chlorine compounds Bicyclic compound Dicarboxylic acid Enantiomer(-) Organic fluorine compounds In vitro Pharmacokinetics Penetration Structure activity relation Group II mglu glutamate receptor Chemical synthesis Central nervous system Selectivity Oral administration
- Keyword (es)
- Absorción Aminoácido Antagonista Compuesto bicíclico Diácido carboxílico Enantiómero(-) In vitro Farmacocinética Penetración Relación estructura actividad Receptor glutamato grupo II Síntesis química Sistema nervioso central Selectividad Vía oral
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09E Glutamatergic system (aspartate and other excitatory aminoacids)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16040976
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0400294 
https://dx.doi.org/10.1021/jm0400294
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