New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of THIQ
- Author
- MUTULIS, Felikss; YAHORAVA, Sviatlana; RINKEN, Ago; WIKBERG, Jarl E. S; MUTULE, Ilze; YAHORAU, Aleh; LIEPINSH, Edvards; KOPANTSHUK, Sergei; VEIKSINA, Santa; TARS, Kaspars; BELYAKOV, Sergey; MISHNEV, Anatoly
Department of Cell and Molecular Biology, Uppsala University, Box 596, 751 24 Uppsala, Sweden
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 171 77 Stockholm, Sweden
Department of Pharmaceutical Biosciences, Division of Pharmacology, Uppsala University, Box 591, Biomedicum, 751 24 Uppsala, Sweden
Institute of Organic and Bioorganic Chemistry, Tartu University, Jakobi 2, 51014 Tartu, Estonia
Latvian Institute of Organic Synthesis, 1006, Riga, Latvia - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 18, pp 4613-4626, 14 p ; ref : 51 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Chlore composé organique Cyclohexane dérivé In vitro Isoquinoléine dérivé Ligand Pipérazine dérivé Récepteur mélanocortine MC4 Structure cristalline Synthèse chimique Triazole dérivé α-Aminoacide Phénylalanine(4-chloro-Nα-[1,2,3,4-tétrahydro-3-isoquinolyl])pipérazide[4-2-[1,2,4-triazol-1-yl]cyclohexyl] Phénylalanine(4-chloro-Nα-[1,2,3,4-tétrahydro-3-isoquinolyl])pipéridide[4-cyclohexyl-4-(1,2,4-triazol-1-ylméthyl)]
- Keyword (en)
- Biological activity Organic chlorine compounds Cyclohexane derivatives In vitro Isoquinoline derivatives Ligand Piperazine derivatives MC4 melanocortin receptor Crystalline structure Chemical synthesis Triazole derivatives α-Aminoacid
- Keyword (es)
- Actividad biológica Ciclohexano derivado In vitro Isoquinoleína Ligando Piperazina derivado Receptor melanocortina MC4 Estructura cristalina Síntesis química Triazol derivado α-Aminoácido
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09F Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16040980
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0311285 
https://dx.doi.org/10.1021/jm0311285
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