Substituted piperazines as novel dipeptidyl peptidase IV inhibitors
- Author
- BROCKUNIER, Linda L1 ; JIAFANG HE1 ; WU, Joseph K2 ; THORNBERRY, Nancy A2 ; WEBER, Ann E1 ; PARMEE, Emma R1 ; COLWELL, Lawrence F1 ; HABULIHAZ, Bahanu1 ; HUAIBING HE1 ; LEITING, Barbara2 ; LYONS, Kathryn A1 ; MARSILIO, Frank2 ; PATEL, Reshma A2 ; TEFFERA, Yohannes3
[1] Department of Medicinal Chemistry, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, United States
[2] Department of Metabolic Disorders, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, United States
[3] Department of Drug Metabolism, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 18, pp 4763-4766, 4 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Dipeptidyl-peptidase IV Hétérocycle azote Inhibiteur enzyme Peptide Pipérazine dérivé Relation structure activité Synthèse chimique Sélectivité Composé bas poids moléculaire Inhibiteur DPIV Enzyme Fluor Composé organique Hydrolases Peptidases
- Keyword (en)
- Dipeptidyl-peptidase IV Nitrogen heterocycle Enzyme inhibitor Peptides Piperazine derivatives Structure activity relation Chemical synthesis Selectivity Low molecular weight compound Enzyme Fluorine Organic compounds Hydrolases Peptidases
- Keyword (es)
- Dipeptidyl-peptidase IV Heterociclo nitrógeno Inhibidor enzima Péptido Piperazina derivado Relación estructura actividad Síntesis química Selectividad Enzima Fluor Compuesto orgánico Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02E Enzymes and enzyme inhibitors / 002A02E04 Hydrolases
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- Analytical, structural and metabolic biochemistry General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16069547
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.06.065 
https://dx.doi.org/10.1016/j.bmcl.2004.06.065
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