Synthesis of ethyleneoxide modified 3-carboranyl thymidine analogues and evaluation of their biochemical, physicochemical, and structural properties
- Author
- JOHNSAMUEL, Jayaseharan1 ; LAKHI, Nisha1 ; AL-MADHOUN, Ashraf S2 ; YOUNGJOO BYUN1 ; JUNHUA YAN1 ; ERIKSSON, Staffan2 ; TJARKS, Werner1
[1] College of Pharmacy, The Ohio State University, Columbus, OH 43210, United States
[2] Department of Molecular Biosciences, Section of Veterinary Medicinal Chemistry, Swedish University of Agricultural Sciences, The Biomedical Center, 75123, Uppsala, Sweden - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 18, pp 4769-4781, 13 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Bore Composé organique Carborane Complexe enzyme substrat Composé cage Ethylène oxyde polymère Homme Modèle moléculaire Modélisation Oligomère Phosphorylation Propriété biologique Propriété physicochimique Pyrimidine nucléoside Relation structure fonction Site actif Substrat Synthèse chimique Thymidine kinase Thymidine dérivé Enzyme Phosphore Composé organique Transferases
- Keyword (en)
- Boron Organic compounds Carborane Substrate enzyme complex Cage compound Ethylene oxide polymer Human Molecular model Modeling Oligomer Phosphorylation Biological properties Physicochemical properties Pyrimidine nucleoside Structure function relationship Active site Substrate Chemical synthesis Thymidine kinase Enzyme Phosphorus Organic compounds Transferases
- Keyword (es)
- Boro Compuesto orgánico Carborano Complejo enzima sustrato Compuesto jaula Etileno óxido polímero Hombre Modelo molecular Modelización Oligómero Fosforilación Propiedad biológica Propiedad fisicoquímica Pirimidina nucleósido Relación estructura función Lugar activo Substrato Síntesis química Thymidine kinase Enzima Fósforo Compuesto orgánico Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002A Fundamental and applied biological sciences. Psychology / 002A02 Analytical, structural and metabolic biochemistry / 002A02E Enzymes and enzyme inhibitors / 002A02E03 Transferases
- Discipline
- Analytical, structural and metabolic biochemistry
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16072645
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.07.032 
https://dx.doi.org/10.1016/j.bmc.2004.07.032
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