Substrate depletion approach for determining in vitro metabolic clearance: Time dependencies in hepatocyte and microsomal incubations
- Author
- JONES, Hannah M1 ; HOUSTON, J. Brian1
[1] Centre for Applied Pharmaceutical Research, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom - Source
Drug metabolism and disposition. 2004, Vol 32, Num 9, pp 973-982, 10 p ; ref : 36 ref
- CODEN
- DMDSAI
- ISSN
- 0090-9556
- Scientific domain
- Pharmacology drugs
- Publisher
- American Society for Pharmacology and Experimental Therapeutics, Bethesda, MD
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Clairance Déplétion Hépatocyte In vitro Incubation Microsome Métabolisme Appareil digestif Foie Pharmacocinétique
- Keyword (en)
- Clearance Depletion Hepatocyte In vitro Incubation Microsome Metabolism Digestive system Liver Pharmacokinetics
- Keyword (es)
- Depuración Depleción Hepatocito In vitro Incubación Microsoma Metabolismo Aparato digestivo Hígado Farmacocinética
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16072846
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1124/dmd.104.000125 
https://dx.doi.org/10.1124/dmd.104.000125
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