Impaired degradation of mutant α-synuclein by chaperone-mediated autophagy
- Author
- CUERVO, Ana Maria1 ; STEFANIS, Leonidas2 3 ; FREDENBURG, Ross4 ; LANSBURY, Peter T4 ; SULZER, David5
[1] Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, United States
[2] Neurobiology Laboratory, Foundation of Biomedical Research of the Academy of Athens, Athens 11527, Greece
[3] Department of Neurology and Pathology, Columbia University, New York, NY 10032, United States
[4] Center for Neurologic Diseases, Brigham and Women's Hospital, Department of Neurology, Harvard Medical School, Cambridge, MA 02139, United States
[5] Departments of Psychiatry and Neurology, Columbia University, Department of Neuroscience, New York State Psychiatric Institute, New York, NY 10032, United States - Source
Science (Washington, D.C.). 2004, Vol 305, Num 5688, pp 1292-1295, 4 p
- CODEN
- SCIEAS
- ISSN
- 0036-8075
- Scientific domain
- Multidisciplinary
- Publisher
- American Association for the Advancement of Science, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Autodestruction Chaperon Dégradation Homme Lysosome Mutation Parkinson maladie Pathogénie Autophagie α-Synucléine Encéphale pathologie Extrapyramidal syndrome Maladie dégénérative Système nerveux central pathologie Système nerveux pathologie
- Keyword (en)
- Self destruction Chaperone Degradation Human Lysosome Mutation Parkinson disease Pathogenesis Synuclein Cerebral disorder Extrapyramidal syndrome Degenerative disease Central nervous system disease Nervous system diseases
- Keyword (es)
- Autodestrucción Degradación Hombre Lisosoma Mutación Parkinson enfermedad Patogenia Encéfalo patología Extrapiramidal síndrome Enfermedad degenerativa Sistema nervosio central patología Sistema nervioso patología
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B17 Neurology / 002B17G Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
- Discipline
- Neurology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16090329
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1126/science.1101738 
https://dx.doi.org/10.1126/science.1101738
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