Synthesis and structure-activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium-calcium exchanger
- Author
- KURAMOCHI, Takahiro1 ; KAKEFUDA, Akio1 ; YAMADA, Hiroyoshi1 ; SATO, Ippei1 ; TAGUCHI, Taku2 ; SAKAMOTO, Shuichi3
[1] Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan
[2] QA & RA Division, Yamanouchi Pharmaceutical Co. Ltd, 3-17-1 Hasune, Itabashi-Ku, Tokyo 174-8612, Japan
[3] Institute for Technology Development, Yamanouchi Pharmaceutical Co. Ltd, 160-2 akahama, Takahagi, Ibaraki 318-0001, Japan - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 19, pp 5039-5056, 18 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Appareil circulatoire pathologie Benzène dérivé Calcium Ion Carboxamide Coeur Ether Hétérocycle azote Hétérocycle soufre In vitro Inhibition Ischémie myocarde Myocyte Protéine transport Pyridine dérivé Relation structure activité Sodium Ion Synthèse chimique Thiophène dérivé Traitement Transport biologique Vaisseau sanguin pathologie Nicotinamide(N-benzyl-6-[4-(3-fluorobenzyloxy)phénoxy]) Pyrrolidine-1-acétamideN-[6-(4-[(3-thiényl)méthoxy]phénoxy)-3-pyridyl] Fluor Composé organique
- Keyword (en)
- Cardiovascular disease Benzene derivatives Calcium Ions Carboxamide Heart Ether Nitrogen heterocycle Sulfur heterocycle In vitro Inhibition Myocardial ischemia Myocyte Carrier protein Pyridine derivatives Structure activity relation Sodium Ions Chemical synthesis Thiophene derivatives Treatment Biological transport Vascular disease Fluorine Organic compounds
- Keyword (es)
- Aparato circulatorio patología Benceno derivado Calcio Ión Carboxamida Corazón Eter Heterociclo nitrógeno Heterociclo azufre In vitro Inhibición miocardio isquemia Miocito Proteína transportador Piridina derivado Relación estructura actividad Sodio Ión Síntesis química Tiofeno derivado Tratamiento Transporte biológico Vaso sanguíneo patología Fluor Compuesto orgánico
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02F Cardiovascular system / 002B02F09 Miscellaneous
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16115257
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.07.038 
https://dx.doi.org/10.1016/j.bmc.2004.07.038
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