Structure-activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity
- Author
- SEKINE, Mitsuo1 2 ; OKADA, Kazuhisa1 ; SEIO, Kohji2 3 ; KAKEYA, Hideaki4 ; OSADA, Hiroyuki4 ; SASAKI, Takuma5
[1] Department of Life Science, Tokyo Institute of Technology, Nagatsuda, Midoriku, Yokohama 226-8501, Japan
[2] Frontier Collaborative Research Institute, Tokyo Institute of Technology, Nagatsuda, Midoriku, Yokohama 226-8501, Japan
[3] CREST, JST (Japan Science and Technology Corporation), Nagatsuda, Midoriku, Yokohama 226-8501, Japan
[4] Antibiotics Laboratory, The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
[5] Cancer Research Institute, Kanazawa University, Takara-machi, Kanazawa 920-8640, Japan - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 19, pp 5193-5201, 9 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Anticancéreux Cellule tumorale Cytotoxicité Désoxyribonucléotide Homme In vitro Inhibition Leucémie L1210 Lignée KB Lignée cellulaire Purine nucléotide Pyrimidine nucléotide Relation structure activité Ribonucléotide Souris Synthèse chimique Synthèse peptidique α-Aminoacide Adénosine(7,8-dihydro-8-oxo)-5p-phosphoramidate(O-éthyl-N-prolyl) Désoxyribonucléoside 5p-phosphoramidate(O-éthyl-N-prolyl) Phosmidosine Proline dérivé Ribonucléoside 5p-phosphoramidate(O-éthyl-N-prolyl) Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Antineoplastic agent Tumor cell Cytotoxicity Deoxyribonucleotide Human In vitro Inhibition L1210-Leukemia KB cell line Cell line Purine nucleotide Pyrimidine nucleotide Structure activity relation Ribonucleotide Mouse Chemical synthesis Peptide synthesis α-Aminoacid Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Anticanceroso Célula tumoral Citotoxicidad Desoxirribonucleótido Hombre In vitro Inhibición Leucemia L1210 Célula KB Línea celular Purina nucleótido Pirimidina nucleótido Relación estructura actividad Ribonucleótido Ratón Síntesis química Síntesis peptídica α-Aminoácido Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16115271
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.07.021 
https://dx.doi.org/10.1016/j.bmc.2004.07.021
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