Non-thiol farnesyltransferase inhibitors: Utilization of the far aryl binding site by 5-cinnamoylaminobenzophenones
- Author
- MITSCH, Andreas1 ; WISSNER, Pia1 ; BÖHM, Markus1 ; SILBER, Katrin1 ; KLEBE, Gerhard1 ; SATTLER, Isabel2 ; SCHLITZER, Martin3
[1] Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, 35032 Marburg, Germany
[2] Hans-Knöll-Institut für Naturstoff-Forschung e.V., 07745, Jena, Germany
[3] Department für Pharmazie - Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, 81377 München, Germany - Source
Archiv der Pharmazie (Weinheim). 2004, Vol 337, Num 9, pp 493-501, 9 p ; ref : 35 ref
- CODEN
- ARPMAS
- ISSN
- 0365-6233
- Scientific domain
- Organic chemistry; Pharmacology drugs
- Publisher
- Wiley-VCH, Weinheim
- Publication country
- Germany
- Document type
- Article
- Language
- English
- Author keyword
- Aryl binding site Non-thiol farnesyltransferase inhibitors Structure-activity relation- ships
- Keyword (fr)
- Benzophénone dérivé Benzène dérivé Carboxamide Composé non peptide Composé peptidomimétique Composé vinylique Cycle 6 chaînons Cétone Farnesyl-diphosphate farnesyltransferase Hétérocycle azote In vitro Inhibiteur enzyme Isomère position Modèle moléculaire Modélisation Relation structure activité Site fixation Synthèse chimique Benzèneacétamide dérivé Cinnamamide dérivé Pyridineacrylamide dérivé Enzyme Transferases
- Keyword (en)
- Benzophenone derivatives Benzene derivatives Carboxamide Non peptide compound Peptidomimetic compound Vinylic compound Six membered ring Ketone Farnesyl-diphosphate farnesyltransferase Nitrogen heterocycle In vitro Enzyme inhibitor Position isomer Molecular model Modeling Structure activity relation Binding site Chemical synthesis Enzyme Transferases
- Keyword (es)
- Benzofenona derivado Benceno derivado Carboxamida Compuesto no péptido Compuesto peptidomimético Compuesto vinílico Ciclo 6 eslabones Cetona Farnesyl-diphosphate farnesyltransferase Heterociclo nitrógeno In vitro Inhibidor enzima Isómero posición Modelo molecular Modelización Relación estructura actividad Sitio fijación Síntesis química Enzima Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16118261
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/ardp.200400871 
https://dx.doi.org/10.1002/ardp.200400871
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