Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand
- Author
- MATULENKO, Mark A1 ; SURBER, Bruce2 ; NAMOVIC, Marian T1 ; MORELAND, Robert B1 ; BRIONI, Jorge D1 ; STEWART, Andrew O1 ; FAN, Leimin2 ; KOLASA, Teodozyi1 ; NAKANE, Masaki1 ; TERRANOVA, Marc A1 ; UCHIC, Marie E1 ; MILLER, Loan N1 ; CHANG, Renjie1 ; DONNELLY-ROBERTS, Diana L1
[1] Neuroscienee Research, Global Pharmaceutical Research and Development, Abhott Laboratories, AP9 A/L16, 100 Ahbott Park Road, Abbott Park, IL 60064-6115, United States
[2] Drug Metabolism, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 20, pp 5095-5098, 4 p ; ref : 17 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Agoniste Brome composé organique Catécholamine Dopamine Hydrogène Isotope Ligand Marquage radioisotopique Neurotransmetteur Nitrile Pipérazine dérivé Relation structure activité Récepteur dopaminergique D4 Synthèse chimique Sélectivité Tritium Acétamide dérivé Radioligand
- Keyword (en)
- Agonist Organic bromine compounds Catecholamine Dopamine Hydrogen Isotopes Ligand Radiolabelling Neurotransmitter Nitrile Piperazine derivatives Structure activity relation D4 Dopamine receptor Chemical synthesis Selectivity Tritium
- Keyword (es)
- Agonista Catecolamina Dopamina Hidrógeno Isótopo Ligando Marcación radioisotópica Neurotransmisor Nitrilo Piperazina derivado Relación estructura actividad Receptor dopaminérgico D4 Síntesis química Selectividad Tritio
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02T Contrast media. Radiopharmaceuticals
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16119654
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.07.068 
https://dx.doi.org/10.1016/j.bmcl.2004.07.068
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