Synthesis and AMPA receptor antagonistic activity of a novel 7-imidazolyl-6-trifluoromethyl quinoxalinecarboxylic acid with a substituted phenyl group and improved its good physicochemical properties by introduced CF3 group
- Author
- TAKANO, Yasuo1 ; SHIGA, Futoshi1 ; ASANO, Jun1 ; HORI, Wataru1 ; ANRAKU, Tsuyosi1 ; UNO, Takashi1
[1] Discovery Research Laboratories, Kyorin Pharmaceutical Co., Ltd, Nogi-machi 2399-1, Simotsuga-gun, Tochigi 329-0114, Japan - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 20, pp 5107-5111, 5 p ; ref : 16 ref
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide carboxylique Activité biologique Antagoniste Carbamate organique Fluor composé organique Hydrosolubilité Imidazole dérivé In vitro In vivo Neuroprotecteur Propriété physicochimique Quinoxaline dérivé Récepteur AMPA Récepteur glutamate Stabilité Synthèse chimique Sélectivité
- Keyword (en)
- Carboxylic acid Biological activity Antagonist Organic carbamate Organic fluorine compounds Water solubility Imidazole derivatives In vitro In vivo Neuroprotective agent Physicochemical properties Quinoxaline derivatives AMPA receptor Glutamate receptor Stability Chemical synthesis Selectivity
- Keyword (es)
- Acido carboxílico Actividad biológica Antagonista Carbamato orgánico Hidrosolubilidad Imidazol derivado In vitro In vivo Neuroprotector Propiedad fisicoquímica Quinoxalina derivado Receptor AMPA Receptor glutámato Estabilidad Síntesis química Selectividad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09E Glutamatergic system (aspartate and other excitatory aminoacids)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B10 Neuroprotective agent
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16119657
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.07.093 
https://dx.doi.org/10.1016/j.bmcl.2004.07.093
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