Synthesis and activity of novel analogs of hemiasterlin as inhibitors of tubulin polymerization: modification of the A segment
- Author
- YAMASHITA, Ayako1 ; NORTON, Emily B1 ; ZASK, Arie1 ; AYRAL-KALOUSTIAN, Semiramis1 ; KAPLAN, Joshua A1 ; CHUAN NIU1 ; LOGANZO, Frank1 ; HERNANDEZ, Richard1 ; BEYER, Carl F1 ; ANNABLE, Tami1 ; MUSTO, Sylvia1 ; DISCAFANI, Carolyn1
[1] Chemical and Screening Sciences and Oncology Research, Wyeth Research, Pearl River, NY 10965, United States - Source
Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 21, pp 5317-5322, 6 p
- ISSN
- 0960-894X
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Anticancéreux Antimitotique Antitubuline Cellule tumorale Composé aromatique Cytotoxicité Epiderme Glycoprotéine P Homme In vitro Lignée KB Lignée cellulaire Protéine transmembranaire Protéine transport Relation structure activité Résistance Synthèse chimique HTI 286 Hémiasterline
- Keyword (en)
- Antineoplastic agent Antimitotic Antitubulin Tumor cell Aromatic compound Cytotoxicity Epidermis P Glycoprotein Human In vitro KB cell line Cell line Transmembrane protein Carrier protein Structure activity relation Resistance Chemical synthesis
- Keyword (es)
- Anticanceroso Antimitótico Antitubulina Célula tumoral Compuesto aromático Citotoxicidad Epidermis Glicoproteína P Hombre In vitro Célula KB Línea celular Proteína transmembranar Proteína transportador Relación estructura actividad Resistencia Síntesis química
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16148950
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2004.08.024 
https://dx.doi.org/10.1016/j.bmcl.2004.08.024
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