Synthesis and biological evaluation of bicyclic and tricyclic substituted nortropane derivatives: discovery of a novel selective α1D-adrenergic receptor ligand
- Author
- MCGINTY, Susan J1 ; FINCH, Angela2 ; GRIFFITH, Renate3 ; GRAHAM, Robert M2 ; BREMNER, John B1
[1] Institute for Biomolecular Science and Department of Chemistry, University of Wollongong, Northfields Ave, Wollongong, NSW, 2522, Australia
[2] Victor Chang Cardiac Research Institute, Darlinghurst, Sydney, NSW, 2010, Australia
[3] School of Environmental and Life Sciences, University of Newcastle, Callaghan, NSW, 2308, Australia - Source
Bioorganic & medicinal chemistry. 2004, Vol 12, Num 21, pp 5639-5650, 12 p ; ref : 29 ref
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activité biologique Acétal Affinité Composé bicyclique Composé tricyclique Hémiacétal In vitro Ligand Récepteur α1D-adrénergique Spirane Synthèse chimique Sélectivité 8-Azabicyclo[3.2.1]octane dérivé 8-Oxa-9-azatricyclo[3.2.1.13,7]octan-5-ol(1-phényl) Nortropane dérivé Nortropane-3β,6α-diol(6β-phényl)
- Keyword (en)
- Biological activity Acetal Affinity Bicyclic compound Tricyclic compound Hemiacetal In vitro Ligand α1D-adrenergic receptor Spiran Chemical synthesis Selectivity
- Keyword (es)
- Actividad biológica Acetal Afinidad Compuesto bicíclico Compuesto tricíclico Hemiacetal In vitro Ligando Receptor α1D-adrenérgico Espirano Síntesis química Selectividad
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09A Catecholaminergic system
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16172240
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.07.063 
https://dx.doi.org/10.1016/j.bmc.2004.07.063
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