In situ click chemistry: Enzyme inhibitors made to their own specifications
- Author
- MANETSCH, Roman1 ; KRASINSKI, Antoni1 ; RADIC, Zoran2 ; RAUSHEL, Jessica1 ; TAVLOR, Palmer2 ; SHARPLESS, K. Barry1 ; KOLB, Hartmuth C1
[1] Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States
[2] Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States - Source
Journal of the American Chemical Society. 2004, Vol 126, Num 40, pp 12809-12818, 10 p ; ref : 52 ref
- CODEN
- JACSAT
- ISSN
- 0002-7863
- Scientific domain
- Biochemistry, molecular biology, biophysics; Chemistry; Organic chemistry; Atomic molecular physics
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acetylcholinesterase Anticholinestérasique Automatisation Chimie combinatoire Chromatographie phase liquide Criblage Inhibiteur enzyme Relation structure activité Relation structure fonction Spectrométrie masse tandem Technologie pharmaceutique Chimiothèque Carboxylic ester hydrolases Enzyme Esterases Hydrolases
- Keyword (en)
- Acetylcholinesterase Anticholinesterase agent Automation Combinatorial chemistry Liquid chromatography Screening Enzyme inhibitor Structure activity relation Structure function relationship Mass spectrometry MS/MS Pharmaceutical technology Chemical compound library Carboxylic ester hydrolases Enzyme Esterases Hydrolases
- Keyword (es)
- Acetylcholinesterase Anticolinesterasa agente Automatización Química combinatoria Cromatografía fase líquida Cernido Inhibidor enzima Relación estructura actividad Relación estructura función Espectrometría masa en tándem Tecnología farmacéutica Carboxylic ester hydrolases Enzima Esterases Hydrolases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02A General pharmacology / 002B02A01 Physicochemical properties. Structure-activity relationships
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16172597
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/ja046382g 
https://dx.doi.org/10.1021/ja046382g
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