Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings
- Author
- NAGARAJAN, Muthukaman1 ; MORRELL, Andrew1 ; FORT, Brian C1 ; MECKLEY, Marintha Rae1 ; ANTONY, Smitha2 ; KOHLHAGEN, Glenda2 ; POMMIER, Yves2 ; CUSHMAN, Mark1
[1] Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907, United States
[2] Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, United States - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 23, pp 5651-5661, 11 p ; ref : 38 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Amine primaire Anticancéreux Cellule tumorale Clivage Complexe enzyme inhibiteur Composé aromatique Composé tétracyclique Cytotoxicité DNA topoisomerase DNA Homme Hétérocycle azote Inhibiteur enzyme Lactame Lignée cellulaire Modèle moléculaire Modélisation Relation structure activité Scission Synthèse chimique Indéno[1,2-c]isoquinoléine-5,11-dione(6-[4-aminobutyl]) chlorhydrate Indénoisoquinoléine Enzyme Isomerases
- Keyword (en)
- Primary amine Antineoplastic agent Tumor cell Cleavage Inhibitor enzyme complex Aromatic compound Tetracyclic compound Cytotoxicity DNA topoisomerase DNA Human Nitrogen heterocycle Enzyme inhibitor Lactam Cell line Molecular model Modeling Structure activity relation Scission Chemical synthesis Enzyme Isomerases
- Keyword (es)
- Amina primaria Anticanceroso Célula tumoral Clivaje Complejo enzima inhibidor Compuesto aromático Compuesto tetracíclico Citotoxicidad DNA topoisomerase DNA Hombre Heterociclo nitrógeno Inhibidor enzima Lactamo Línea celular Modelo molecular Modelización Relación estructura actividad Escisión Síntesis química Enzima Isomerases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16245036
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm040025z 
https://dx.doi.org/10.1021/jm040025z
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