Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K
- Author
- ALTMANN, Eva1 ; COWAN-JACOB, Sandra W1 ; MISSBACH, Martin1
[1] Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 24, pp 5833-5836, 4 p ; ref : 18 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Benzène dérivé Cathepsin K Complexe enzyme inhibiteur Composé bicyclique Composé non peptide Cyclopentane dérivé Hétérocycle azote In vitro Inhibiteur enzyme Inhibition Modèle moléculaire Modélisation Os Pipérazine dérivé Relation structure activité Résorption Site actif Synthèse chimique Purine-2-carbonitrile(7-cyclopentyl-6-[2-(3-[4-méthylpipérazino]propoxy)anilino]) Cysteine endopeptidases Enzyme Hydrolases Peptidases
- Keyword (en)
- Benzene derivatives Cathepsin K Inhibitor enzyme complex Bicyclic compound Non peptide compound Cyclopentane derivatives Nitrogen heterocycle In vitro Enzyme inhibitor Inhibition Molecular model Modeling Bone Piperazine derivatives Structure activity relation Resorption Active site Chemical synthesis Cysteine endopeptidases Enzyme Hydrolases Peptidases
- Keyword (es)
- Benceno derivado Cathepsin K Complejo enzima inhibidor Compuesto bicíclico Compuesto no péptido Ciclopentano derivado Heterociclo nitrógeno In vitro Inhibidor enzima Inhibición Modelo molecular Modelización Hueso Piperazina derivado Relación estructura actividad Resorción Lugar activo Síntesis química Cysteine endopeptidases Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16268483
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0493111 
https://dx.doi.org/10.1021/jm0493111
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