Radiosynthesis and in vivo evaluation of [11C]Ro-647312: a novel NR1/2B subtype selective NMDA receptor radioligand
- Author
- DOLLE, Frédéric1 ; VALETTE, Héric1 ; DEMPHEL, Stéphane1 ; COULON, Christine1 ; OTTAVIANI, Michelle1 ; BOTTLAENDER, Michel1 ; KASSIOU, Michael2 3
[1] Service Hospitalier Frédéric Joliot, Département de Recherche Médicale, CEA/DSV, 4 Place du Général Leclerc, 91401 Orsay, France
[2] Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia
[3] Department of Pharmacology, University of Sydney, NSW 2006, Australia - Source
Journal of labelled compounds & radiopharmaceuticals. 2004, Vol 47, Num 13, pp 911-920, 10 p ; ref : 29 ref
- ISSN
- 0362-4803
- Scientific domain
- Biochemistry, molecular biology, biophysics; Organic chemistry; Pharmacology drugs
- Publisher
- Wiley, Chichester
/
Wiley, New York, NY
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Antagoniste Carbone 11 Carbone Isotope Composé aromatique Composé bicyclique Cycle 6 chaînons Distribution Hétérocycle azote Ligand Marquage radioisotopique Méthane(iodo) Pharmacocinétique Quinoléine dérivé Rat Récepteur NMDA Récepteur glutamate Synthèse chimique Sélectivité Tissu Voie intraveineuse Méthanesulfonique acide(trifluoro) ester méthyle Pyridine(4-diméthylamino-2-[1,2,3,4-tétrahydro-2-quinolyl]) Pyridine(4-méthylamino-2-[1,2,3,4-tétrahydro-2-quinolyl]) Radioligand Radiosynthèse Ro 647312 Sous-unité NMDA R1 Sous-unité NMDA R2B Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Antagonist Carbon 11 Carbon Isotopes Aromatic compound Bicyclic compound Six membered ring Distribution Nitrogen heterocycle Ligand Radiolabelling Iodomethane Pharmacokinetics Quinoline derivatives Rat NMDA receptor Glutamate receptor Chemical synthesis Selectivity Tissue Intravenous administration Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Antagonista Carbono Isótopo Compuesto aromático Compuesto bicíclico Ciclo 6 eslabones Distribución Heterociclo nitrógeno Ligando Marcación radioisotópica Metano(iodo) Farmacocinética Quinolina derivado Rata Receptor NMDA Receptor glutámato Síntesis química Selectividad Tejido Vía intravenosa Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02T Contrast media. Radiopharmaceuticals
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16304509
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1002/jlcr.877 
https://dx.doi.org/10.1002/jlcr.877
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