Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-α converting enzyme and matrix metalloproteinase inhibitors
- Author
- VENKATESAN, Aranapakam M; DAVIS, Jamie M; GUIXIAN JIN; WEIXIN XU; MCCARTHY, Diane Joseph; BARONE, Dauphine; GROSU, George T; BAKER, Jannie; ZASK, Arie; LEVIN, Jeremy I; ELLINGBOE, John; SKOTNICKI, Jerauld S; DIJOSEPH, John F; SUNG, Amy
Amgen, Seattle, Washington 98101, United States
Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States
Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, United States
Wyeth Research, PO Box CN-8000, Princeton, New Jersey 08543, United States - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 25, pp 6255-6269, 15 p ; ref : 31 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Acide hydroxamique Animal Antiinflammatoire Chlore composé organique Composé acétylénique Cytokine Ether Facteur nécrose tumorale α In vitro In vivo Inhibiteur enzyme Metalloendopeptidases Pipéridine dérivé Relation structure activité Souris Sulfone Synthèse chimique Voie orale Inhibiteur metalloendopeptidases Pipéridine-4-carbohydroxamique acide(1-[4-chlorobenzyl]-3-[4-(but-2-ynyloxy)benzènesulfonyl]) Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (en)
- Hydroxamic acid Animal Antiinflammatory agent Organic chlorine compounds Acetylenic compound Cytokine Ether Tumor necrosis factor α In vitro In vivo Enzyme inhibitor Metalloendopeptidases Piperidine derivatives Structure activity relation Mouse Sulfone Chemical synthesis Oral administration Enzyme Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Keyword (es)
- Acido hidroxámico Animal Antiinflamatorio Compuesto acetilénico Citoquina Eter Factor necrosis tumoral α In vitro In vivo Inhibidor enzima Metalloendopeptidases Piperidina derivado Relación estructura actividad Ratón Sulfona Síntesis química Vía oral Enzima Hydrolases Mammalia Peptidases Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02L Bones, joints and connective tissue. Antiinflammatory agents
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16305164
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm040086x 
https://dx.doi.org/10.1021/jm040086x
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