Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group
- Author
- KEMNITZER, William; DREWE, John; MEEROVITCH, Karen; BOUFFARD, David; REJ, Rabindra; DENIS, Real; BLAIS, Charles; LAMOTHE, Serge; ATTARDO, Giorgio; GOURDEAU, Henriette; TSENG, Ben; KASIBHATLA, Shailaja; SONGCHUN JIANG; SUI XIONG CAI; HONG ZHANG; YAN WANG; JIANGHONG ZHAO; SHAOJUAN JIA; HERICH, John; LABREQUE, Denis; STORER, Richard
Maxim Pharmaceuticals, Inc., 6650 Nancy Ridge Drive, San Diego, California 92121, United States
Shire Biochem Inc., 275 Armand-Frappier Blvd., Laval, Quebec H7V 4A7, Canada - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 25, pp 6299-6310, 12 p ; ref : 19 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Activation Aminonitrile Antimitotique Antitubuline Apoptose Brome composé organique Caspase Composé aromatique Criblage Cytotoxicité Glande mammaire Homme Hétérocycle oxygène In vitro Lignée cellulaire Lymphocyte T Relation structure activité Synthèse chimique 1-Benzopyrane dérivé 1-Benzopyrane-3-carbonitrile(2-amino-4-[3-bromo-4,5-diméthoxyphényl]-7-diméthylamino) Lignée JURKAT Lignée T47D Enzyme Hydrolases Peptidases
- Keyword (en)
- Activation Aminonitrile Antimitotic Antitubulin Apoptosis Organic bromine compounds Caspase Aromatic compound Screening Cytotoxicity Mammary gland Human Oxygen heterocycle In vitro Cell line T-Lymphocyte Structure activity relation Chemical synthesis Enzyme Hydrolases Peptidases
- Keyword (es)
- Activación Aminonitrilo Antimitótico Antitubulina Apoptosis Caspase Compuesto aromático Cernido Citotoxicidad Glándula mamaria Hombre Heterociclo oxígeno In vitro Línea celular Linfocito T Relación estructura actividad Síntesis química Enzima Hydrolases Peptidases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16305168
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm049640t 
https://dx.doi.org/10.1021/jm049640t
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