Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-Terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma
- Author
- CATLEY, Laurence1 ; TAI, Yu-Tzu1 ; RICHARDSON, Paul1 ; MUNSHI, Nikhil C1 ; ANDERSON, Kenneth C1 ; SHRINGARPURE, Reshma1 ; BURGER, Renate1 ; SON, Moni Thi1 ; PODAR, Klaus1 ; TASSONE, Pierfrancesco1 ; CHAUHAN, Dharminder1 ; HIDESHIMA, Teru1 ; DENIS, Louis2
[1] Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States
[2] Pfizer Oncology, New London, Connecticut, United States - Source
Cancer research (Baltimore). 2004, Vol 64, Num 23, pp 8746-8753, 8 p ; ref : 50 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Scientific domain
- Medical oncology; Pharmacology drugs
- Publisher
- American Association for Cancer Research, Philadelphia, PA
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- ADP Clivage Cytotoxicité DNA topoisomerase Dégradation Gène onc cellulaire Kinase Mitogen-activated protein kinase Myélome Ribose Régulation Séquence C terminale Antigène Fas Enzyme Hémopathie maligne Immunoglobulinopathie Immunopathologie Isomerases Lymphoprolifératif syndrome Transferases
- Keyword (en)
- ADP Cleavage Cytotoxicity DNA topoisomerase Degradation C-Onc gene Kinase Mitogen-activated protein kinase Myeloma Ribose Regulation(control) C terminal-Sequence Fas Antigen Enzyme Malignant hemopathy Immunoglobulinopathy Immunopathology Isomerases Lymphoproliferative syndrome Transferases
- Keyword (es)
- ADP Clivaje Citotoxicidad DNA topoisomerase Degradación Gen onc celular Kinase Mitogen-activated protein kinase Mieloma Ribosa Regulación Secuencia C terminal Antígeno Fas Enzima Hemopatía maligna Inmunoglobulinopatía Inmunopatología Isomerases Linfoproliferativo síndrome Transferases
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B06 Immunopathology / 002B06D Immunodeficiencies. Immunoglobulinopathies / 002B06D02 Immunoglobulinopathies
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B19 Hematologic and hematopoietic diseases / 002B19B Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
- Discipline
- Blood diseases Immunopathology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16305448
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1158/0008-5472.CAN-04-2894 
https://dx.doi.org/10.1158/0008-5472.CAN-04-2894
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