Synthesis and receptor assay of aromatic-ethynyl-aromatic derivatives with potent mGluR5 antagonist activity
- Author
- ALAGILLE, David1 ; BALDWIN, Ronald M1 ; ROTH, Bryan L2 3 ; WROBLEWSKI, Jarda T4 ; GRAJKOWSKA, Ewa4 ; TAMAGNAN, Gilles D1 5
[1] Department of Psychiatry, Yale University and VA Connecticut/J J6A2, 950 Campbell Avenue, West Haven, CT 06516, United States
[2] Department of Biochemistry and NIMH Psychoactive Drug Screening, Program, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States
[3] NIMH Psychoactive Drug Screening Program, United States
[4] Department of Pharmacology, Georgetown University Medical Center, 3900 Reservoir Road, N. W, Washington, DC 20007, United States
[5] Institute for Neurodegenerative Disorders, 60 Temple Street, Suite 8A, New Haven, CT 06510, United States - Source
Bioorganic & medicinal chemistry. 2005, Vol 13, Num 1, pp 197-209, 13 p
- ISSN
- 0968-0896
- Scientific domain
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Publisher
- Elsevier Science, Oxford
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Keyword (fr)
- Antagoniste Composé acétylénique Composé aromatique Homme In vitro Indole dérivé Isoquinoléine dérivé Pyridine dérivé Quinoléine dérivé Relation structure activité Récepteur glutamate mglu5 Récepteur glutamate Récepteur métabotropique Synthèse chimique Thiazole dérivé Acétylène(1-[5-bromo-3-pyridyl]-2-[6-méthyl-2-pyridyl]) Pyridine(2-méthyl-6-[3-nitrophényléthynyl])
- Keyword (en)
- Antagonist Acetylenic compound Aromatic compound Human In vitro Indole derivatives Isoquinoline derivatives Pyridine derivatives Quinoline derivatives Structure activity relation mglu5 glutamate receptor Glutamate receptor Metabotropic receptor Chemical synthesis Thiazole derivatives
- Keyword (es)
- Antagonista Compuesto acetilénico Compuesto aromático Hombre In vitro Indol derivado Isoquinoleína Piridina derivado Quinolina derivado Relación estructura actividad Receptor glutamato mglu5 Receptor glutámato Receptor metabotropico Síntesis química Tiazol derivado
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02B Neuropharmacology / 002B02B09 Neurotransmitters. Neurotransmission. Receptors / 002B02B09E Glutamatergic system (aspartate and other excitatory aminoacids)
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02W Miscellaneous
- Discipline
- General pharmacology Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16342534
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2004.09.042 
https://dx.doi.org/10.1016/j.bmc.2004.09.042
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