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Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells

Author
BURKE, Patrick J1 ; KALET, Brian T1 ; KOCH, Tad H1
[1] Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, United States
Source

Journal of medicinal chemistry (Print). 2004, Vol 47, Num 26, pp 6509-6518, 10 p ; ref : 38 ref

CODEN
JMCMAR
ISSN
0022-2623
Scientific domain
Pharmacology drugs
Publisher
American Chemical Society, Washington, DC
Publication country
United States
Document type
Article
Language
English
Keyword (fr)
Anthracyclines Anticancéreux Antihormone Antioestrogène Captation Cellule tumorale Composé conjugué Composé non stéroïde DNA topoisomerase (ATP-hydrolysing) Distribution Doxorubicine Ethylène oxyde polymère Formaldéhyde Glande mammaire In vitro Inhibiteur enzyme Lignée cellulaire Relation structure activité Récepteur oestrogène Site fixation Tamoxifène But-1-ène(1,1-diaryl-2-phényl) Salicylique acide dérivé Enzyme Isomerases
Keyword (en)
Anthracyclins Antineoplastic agent Antihormone Antiestrogen Uptake Tumor cell Conjugated compound Non steroid compound DNA topoisomerase (ATP-hydrolysing) Distribution Doxorubicin Ethylene oxide polymer Formaldehyde Mammary gland In vitro Enzyme inhibitor Cell line Structure activity relation Estrogen receptor Binding site Tamoxifene Enzyme Isomerases
Keyword (es)
Antraciclinas Anticanceroso Antihormona Antiestrógeno Captación Célula tumoral Compuesto conjugado Compuesto no esteroide DNA topoisomerase (ATP-hydrolysing) Distribución Doxorubicina Etileno óxido polímero Formaldehído Glándula mamaria In vitro Inhibidor enzima Línea celular Relación estructura actividad Receptor estrógeno Sitio fijación Tamoxifeno Enzima Isomerases
Classification
Pascal
002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects

Discipline
Pharmacological treatments
Origin
Inist-CNRS
Database
PASCAL
INIST identifier
16362041

Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS

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