Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice
- Author
- PATEL, Jyoti B1 ; HUYNH, Carlic K1 2 ; HANDRATTA, Venkatesh D1 ; GEDIYA, Lalji K1 ; BRODIE, Angela M. H1 ; GOLOUBEVA, Olga G3 ; CLEMENT, Omoshile O4 ; NANNE, Ivo P5 ; SOPRANO, Dianne Robert6 ; NJAR, Vincent C. O1
[1] Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, Baltimore, Maryland 21201-1559, United States
[2] Program in Toxicology, University of Maryland School of Medicine, 10 South Pine Street, MSTF 7-34F, Baltimore, Maryland 21201-1559, United States
[3] Biostatistics Division, University of Maryland Greenebaum Cancer Center, Baltimore, Maryland 21201-1559, United States
[4] Accelrys, 9685 Scranton Road, San Diego, California 92121, United States
[5] Department of Pharmaceutical Sciences, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, Pennsylvania 19140, United States
[6] Department of Biochemistry and Fels Institute of Cancer Research & Molecular Biology, Temple University School of Medicine, 3400 North Broad Street, Philadelphia, Pennsylvania 19140, United States - Source
Journal of medicinal chemistry (Print). 2004, Vol 47, Num 27, pp 6716-6729, 14 p ; ref : 52 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Scientific domain
- Pharmacology drugs
- Publisher
- American Chemical Society, Washington, DC
- Publication country
- United States
- Document type
- Article
- Language
- English
- Keyword (fr)
- Animal Anticancéreux Cellule tumorale Glande mammaire Homme Imidazole dérivé In vitro In vivo Inhibiteur Multiplication cellulaire Prostate Relation structure activité Rétinoïque acide Souris Synthèse chimique Tumeur maligne Lignée LNCAP Lignée MCF7 Lignée T47D Rétinoïque acide(4-[imidazol-1-yl]) ester méthyle Rétinoïque acide(4-[imidazol-1-yl]) Mammalia Rodentia Vertebrata
- Keyword (en)
- Animal Antineoplastic agent Tumor cell Mammary gland Human Imidazole derivatives In vitro In vivo Inhibitor Cell proliferation Prostate Structure activity relation Retinoic acid Mouse Chemical synthesis Malignant tumor Mammalia Rodentia Vertebrata
- Keyword (es)
- Animal Anticanceroso Célula tumoral Glándula mamaria Hombre Imidazol derivado In vitro In vivo Inhibidor Multiplicación celular Prostata Relación estructura actividad Retinoico ácido Ratón Síntesis química Tumor maligno Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B02 Pharmacology. Drug treatments / 002B02R Antineoplastic agents / 002B02R01 General aspects
- Discipline
- Pharmacological treatments
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 16385016
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1021/jm0401457 
https://dx.doi.org/10.1021/jm0401457
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